摘要
目的:探讨碘摄入与甲状腺功能的关系,以期指导临床合理补碘。方法:2010年1～2月因身材矮小收入我院内分泌科进行相关检查的患儿为研究对象,依据甲状腺功能情况分为3组:亚临床甲减组(SCH组)、临床甲减组(CH组)和甲状腺功能正常组(正常组);所有病例进行甲状腺功能、晨起空腹尿碘测定等。并对SCH组患儿进行随访。结果:1 689例矮小患儿中,碘摄入不足65例(3.8%),碘过量593例(35.2%),碘摄入正常1031例(61.1%)。SCH 105例(6.2%)、CH 23例(1.4%)、正常1 586例(92.4%)。105例SCH中,高尿碘78例(74.2%)。高尿碘发生率SCH组显著高于CH组和正常组(P<0.01),SCH组、CH组、正常组尿碘中位数分别为389.38μg/L、136.21μg/L、221.52μg/L。经过饮食干预和(或)甲状腺素替代治疗3个月后,尿碘均正常,7例TSH仍增高。结论:碘摄入过多可能是儿童亚临床甲减的重要原因,尿碘检测应成为儿童常规的检测项目,发现异常及时干预可减少对儿童体格和智力的影响。
Objective：To investigate the relation between iodine intake and thyroid function to guide the rational iodine supplement.Methods：The short stature children as the research objects were admitted to the endocrinological department during January 2010 to February 2011 and divided into three groups according to the thyroid function： subclinical hypothyroidism group（SCH）,clinical hypothyroidism group（CH） and normal group.The thyroid function and urine iodine were detected in all the research objects.The children patients in SCH were followed up.Results：In 1689 short stature children,65 cases were inadequate iodine intake（3.8%）,593 cases were excess iodine intake,（35.2%） and 1031 were normal iodine intake（61.1%）.105 cases（6.2%） were SCH,23 cases（1.4%） were CH and 1586 cases（92.4%） were normal thyroid function.78 cases（74.2%） were excess iodine intake in SCH group.The incidence rate of high urinary iodine in SCH group was more than that in CH group and the normal group（P0.01）.The median iodine concentration in urine were 389.38 μg/L,136.21 μg/L and 221.52 μg/L in SCH group,CH group and the normal group respectively.After three months of dietary interventions and thyroxin replacing treatment,most of cases in SCH group were normal urine iodine and normal thyroid function.7 cases still had higher TSH.Conclusion：Excessive iodine intake may be the important reason for subclinical hypothyroidism in children.Hence the urine iodine detection should be taken as a routine detection item in children.Discovering abnormality and timely intervention can reduce the influence on the body and intelligence of children.
出处
《现代医药卫生》
2011年第17期2574-2575,共2页
Journal of Modern Medicine & Health
关键词
儿童
尿碘
碘摄入过量
甲状腺功能减退
亚临床
Children
Urine iodine
Excessive iodine intake
Hypothyroidism
Subclinical
