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盐酸伊立替康脂质体载药方式的研究进展 被引量：3

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摘要 目的:介绍盐酸伊立替康(CPT-11)脂质体的载药方式,为其进一步研发提供参考。方法:根据文献,综述了硫酸铵梯度法、pH梯度法、二价阳离子载体A23187联合硫酸铜溶液法、金属离子梯度法和六磷酸肌醇作为载入剂等5种CPT-11脂质体的载药方式。结果与结论:利用上述载药方式所制备的CPT-11脂质体的包封率均大于90%。随着脂质体制备和研究技术的不断提高,开发长效、靶向的CPT-11脂质体,进而提高药物的治疗指数、优化药物的给药剂量和降低药物的毒副作用,已成为国内、外学者研究的热点。
作者 赵广波 白靖 王静 曹德英
机构地区 河北医科大学药学院
出处 《中国药房》 CAS CSCD 北大核心 2011年第37期3536-3538,共3页 China Pharmacy
关键词 盐酸伊立替康 脂质体 载药方式 研究进展
分类号 R94 [医药卫生—药剂学]
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参考文献17

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二级参考文献12

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中国药房
2011年 第37期

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