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替罗非班对急性心肌梗死患者介入术后早期炎性因子水平的影响 被引量：4

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摘要 目的观察GPⅡb/Ⅲa受体拮抗剂-替罗非班(tirofiban)对急性心肌梗死(acute myocardial infarction,AMI)患者经皮冠状动脉介入术(percutaneous coronary intervention,PCI)治疗后可溶性CD40配体(sCD40L)、白细胞介素-18及高敏C反应蛋白水平的影响。方法收集接受PCI治疗的AMI住院患者32例,随机分为替罗非班组及对照组,每组各16例。在常规用药的基础上,替罗非班组在PCI术开始即刻应用盐酸替罗非班氯化钠注射液。测定sCD40L、高敏C反应蛋白(hs-CRP)、白细胞介素-18(IL-18)的水平。结果替罗非班组PCI术后3及24 h炎性因子水平明显低于对照组(P<0.05)。结论 PCI术后存在炎性反应,sCD40L、IL-18、hs-CRP是反映PCI术后早期炎性反应的敏感指标,它的变化程度对不良心血管事件的发生可能具有预测价值。应用替罗非班后血清炎性因子的水平降低更加显著,对预防AMI患者进一步的心脏缺血事件有积极作用。
作者 全昌发 陈君
机构地区 湖南省衡阳市第一人民医院
出处 《实用预防医学》 CAS 2011年第9期1749-1750,共2页 Practical Preventive Medicine
关键词 急性心肌梗死 可溶性CD40配体 白细胞介素-18 高敏C反应蛋白
分类号 R542.2 [医药卫生—心血管疾病]
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参考文献11

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共引文献102

同被引文献27

  • 1王静,郑刚,张德铭,黄自平,杜闻莹.老年急性心肌梗死患者临床特征的回顾性分析[J].中国医药导刊,2007,9(2):116-118. 被引量：1
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  • 7Anand Alurkar,Lakshmi Sudha Prasanna Karanam,Sagar Oak,Suresh Nayak,Sandeep Sorte.Role of Balloon-Expandable Stents in Intracranial Atherosclerotic Disease in a Series of 182 Patients[J].Stroke.2013(7)
  • 8Zongdan Jiang,Hailu Wu,Zhaotao Duan,Zhibing Wang,Kewei Hu,Fei Ye,Zhenyu Zhang.Proton-pump inhibitors can decrease gastrointestinal bleeding after percutaneous coronary intervention[J].Clinics and Research in Hepatology and Gastroenterology.2013
  • 9Barry Scott,Naseem Ghazali,Derek Lowe,Fazilet Bekiroglu,Simon N. Rogers.The Patients Concerns Inventory in head and neck cancer: Comparison between self-completed paper and touch screen versions in the clinic setting[J].European Journal of Oncology Nursing.2013
  • 10Futoshi Yamanaka,Myung Ho Jeong,Shigeru Saito,Youngkeun Ahn,Shung Chull Chae,Seung Ho Hur,Taek Jong Hong,Young Jo Kim,In Whan Seong,Jei Keon Chae,Jay Young Rhew,In Ho Chae,Myeong Chan Cho,Jang Ho Bae,Seung Woon Rha,Chong Jin Kim,Donghoon Choi,Yang Soo Jang,Junghan Yoon,Wook Sung Chung,Jeong Gwan Cho,Ki Bae Seung,Seung Jung Park.Comparison of clinical outcomes between octogenarians and non-octogenarians with acute myocardial infarction in the drug-eluting stent era: Analysis of the Korean Acute Myocardial Infarction Registry[J].Journal of Cardiology.2013

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实用预防医学
2011年 第9期

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