摘要
目的观察阿仑膦酸钠治疗绝经后骨质疏松症患者的骨密度变化。方法回顾性分析门诊120例绝经后骨质疏松患者,其中对照组88例,单纯补充钙剂(600 mg/日)及活性维生素D(0.25μg/日),治疗组32例,补充钙剂及活性维生素D的基础上同时服用阿仑膦酸钠70mg每周一次。观察两组治疗一年后骨密度的变化。结果对照组腰椎2-4部位骨密度由治疗前(0.763±0.098)g/cm2降至治疗后(0.742±0.095)g/cm2,差异有统计学意义(P=0.000);股骨颈部位骨密度由基线水平(0.637±0.073)g/cm2降至(0.601±0.078)g/cm2,差异有统计学意义(P=0.006)。阿仑膦酸钠治疗后腰椎2-4骨密度由(0.729±0.122)g/cm2升至(0.743±0.129)g/cm2,差异有统计学意义(P=0.007);股骨颈部位骨密度由治疗前(0.599±0.086)g/cm2升至治疗后(0.635±0.112)g/cm2,差异有统计学意义(P=0.000)。结论阿仑膦酸钠可增加绝经后骨质疏松患者的骨密度;单纯补充钙剂及维生素D治疗不能防止绝经后妇女骨量的进一步丢失。
Objective To investigate the change of bone mineral density （BMD） in postmenopausal osteoporotie patients after alendronate treatment. Methods The data of 120 postmenopausal osteoporotie patients were retrospectively analyzed. They were divided into the control group with 88 cases treated with 600 mg calcium and O. 25 ug calcitriol daily and the treatment group with 32 cases treated with 70 mg alendronate weekly in addition of calcium and vitamin D uptake. The changes of BMD in both groups were observed after 1 year. Results BMD of the lumbar vertebra 2-4 in control groups decreased from 0. 763 ＋ 0. 098 g,/cm2 before the treatment to 0.742 2 0. 095 g/era： after the treatment, and the difference was statistically significant （P = 0. 000）. Compared to baseline, BMD of the femoral neck in control groups decreased from 0. 637 ± 0. 073 g/cm2 to 0. 601±0. 078 g/cm2, and the difference was statistically significant （ P = 0. 006）. After alendronate treatment, BMD of the lumbar vertebra 2-4 increased from 0. 729 2 0. 122g/cm2 to 0. 743 2 0. 129 g/cm2, and the difference was statistically significant （P = 0.007 ）. BMD of the femoral neck inereased from 0. 599 20. 086 g/cm： to 0. 635 20. 112 g/cm2, and the difference was statistically significant （P = 0. 000）. Conclusion Alendronate can increase BMD in postmenopausal osteoporosis patients. The treatment of calcium and vitamin D only cannot prevent further loss of bone mass.
出处
《中国骨质疏松杂志》
CAS
CSCD
2011年第9期818-820,共3页
Chinese Journal of Osteoporosis
基金
首都医学发展科研基金项目(20073029)
关键词
绝经后骨质疏松症
阿仑膦酸钠
骨密度
Postmenopausal osteoporosis
Alendronate
Bone mineral density
