摘要
目的探讨国产舍曲林与进口舍曲林治疗抑郁症的疗效与安全性。方法对57例抑郁症患者分别给予国产舍曲林(唯他停组,29例)和进口舍曲林(左洛复组,28例)治疗,疗程为8周。采用汉密尔顿抑郁量表(HAMD)及不良反应量表(TESS)在治疗前及治疗8周末评定疗效和不良反应。结果两组患者疗效间差异无统计学意义(P>.05)。唯他亭组出现不良反应15例(51.7%),左洛复组出现不良反应12例(42.9%),两组患者不良反应发生率间差异无统计学意义(P>0.05)。结论唯他停和左洛复的疗效和安全性无显著差异,但唯他停更经济,是临床治疗的较佳选择。
Objective To explore the efficacy and safety between Sertraline （made in China） and Zoloft in the treatment of depression. Methods 57 patients were randomly divided into sortraline （made in China） group （n = 29） and zoloft group （n = 28） for 8 weeks. The clinical efficaeies were assessed with the Hamilton depressive scale （HAMD） and adverse effects with the treatment emergant symptom scale （TESS） before treatment and at the ends of the 8th week treatment. Results There was no signhqeant difference in the curative effect between two groups after 8 - week （ P 〉 0. 05 ）. Adverse effects of both groups were mild. Conclusion Sertraline （made in China） has an equivalent efficacy to zoloft, but sertraline （made in China） has less prices and has good choose.
出处
《临床合理用药杂志》
2011年第05X期44-45,共2页
Chinese Journal of Clinical Rational Drug Use
关键词
舍曲林
抑郁症
Sertraline
Deprressive disorder
