摘要
目的分析酵母遗传相互作用的基因组尺度的总体性质。方法用网络的图论方法,计算酵母遗传相互作用网络的拓扑性质。结果酵母全基因组的遗传相互作用中,基因的相互作用个数服从幂律分布,幂指数接近3。平均相互作用的基因为87,约2/3的基因只需通过1个基因就有遗传相互作用,约1/3只需通过2个基因就有遗传相互作用。遗传相互作用网络的平均聚集系数是0.047。结论酵母的基因通常具有多种而不是单一的功能,而且基因之间遗传相互作用高度密集。
Objective To analyze the topological properties of genomic-wide genetic interaction network in yeast.Methods The topological properties of genomic-wide genetic interaction network in yeast were calculated by the graph theory.Results A power law fit the degree distribution well in the genomic-wide genetic interaction network in yeast,with the exponent approaching 3.The Node＇s degree followed a wide-tail distribution,with the average degree being 87.Two thirds of the genes had genetic interaction via only one gene,and about one third of the genes had genetic interaction via only 2 genes.The average clustering coefficient was 0.047.Conclusion The gene function in yeast is usually multiple and the functional interaction between genes is highly condensed.
出处
《第二军医大学学报》
CAS
CSCD
北大核心
2011年第9期1009-1012,共4页
Academic Journal of Second Military Medical University
