摘要
高迁移率族蛋白A（HMGA）在多种肿瘤的发生发展中起着重要的作用，其表达水平会随肿瘤恶性程度的增高或转移潜能的增大而异常增高。let-7是一类内源性非编码的微小RNA，可作为肿瘤抑制因子对HMGA基因进行负性调控。在对多种肿瘤的研究中已经观察到let-7表达水平的下降，并伴随HMGA表达水平的上升，这对肿瘤的早期诊断提供了新的参考依据，并对肿瘤的治疗提供了新的途径。
High mobility group protein A （HMGA） plays a critical role in the development of a variety of tumors. It＇s expression level will abnormally increase with the increase of the malignant degrees of astrocytoma and metastasis potential. Let-7 which is a kind of small RNA endogenous coding negatively regulates HMGA genes as a tumor suppressor. The expression of let-7 reduces while HMGA rises in many kinds of tumors was obversed. Therefore, this finding provides new references for the early diagnosis of tumor and also provides new approaches for therapy of tumor.
出处
《国际肿瘤学杂志》
CAS
2011年第9期646-649,共4页
Journal of International Oncology
