摘要
目的了解治疗后子宫内膜癌患者的生活质量,比较不同的治疗方法对其生活质量的影响,为临床选择个体化治疗方案提供参考。方法 随访2002年1月至2008年12月于北京大学人民医院手术治疗的子宫内膜癌患者,评估并比较经不同方法治疗的患者生活质量。结果Ⅰ期及未合并其他恶性肿瘤的子宫内膜癌患者,接受手术+内分泌治疗者(n=87),其躯体功能、角色功能、总健康状况均优于单纯手术者(n=36),且较少发生疲倦症状;其躯体功能、角色功能优于手术+放/化疗者(n=43);但其围绝经期症状较接受手术+内分泌治疗+放/化疗者(n=55)严重;手术+内分泌治疗+放/化疗者,其躯体功能优于单纯手术者(P<0.008)。Ⅱ期以上及合并其他恶性肿瘤患者,各治疗组间生活质量差异不明显。结论辅助内分泌治疗可以提高Ⅰ期子宫内膜癌患者的生活质量;积极的放/化疗可能会提高Ⅱ期及以上患者的生活质量,尚需大样本量的研究。
Objective The purpose of this study was to assess the quality of life of the patients with endometrial cancer after treatment,and to understand their quality of life status,analysis the effects of different treatment methods on patients＇ quality of life.Methods Endometrial cancer patients who underwent surgical treatment in Peking university people＇s hospital from January 2002 to December 2008 were interviewed with general socia-demographic characteristics and the quality of life.Patients＇ quality of life were compared between different treatments gnoups.Results Patients with stage Ⅰ without any other cancer were treated by surgery ＋ hormonal therapy（n=87）,their physical function,role function,global health status were better than those treated by surgery alone（n=36）,and also better than the patients with surgery ＋ radiotherapy/chemotherapy（n=43）,but their perimenopausal symptoms were more than patients with surgery ＋ hormonal therapy ＋ radiaotherapy/chemotherapy（n=55）.For those patients who underwent surgery ＋ hormonal therapy ＋ radiotherapy/chemotherapy treatment,the physical function were better than those treated with surgery alone（P0.008）.For patients with stage Ⅱ or more advanced stages or with other concomitant cancer,despite the different kinds of treatments,the quality of life had no significant difference（P0.05）.Conclusions For stage Ⅰ patients with endometrial cancer,treated with adjuvant hormonal therapy can improve the quality of life.For stage Ⅱ and more advanced patients,treating with active radiotherapy/chemotherapy may improve their quality of life which still need a larger sample to study.
出处
《中国妇产科临床杂志》
2011年第5期327-330,共4页
Chinese Journal of Clinical Obstetrics and Gynecology
基金
北京大学医学部“985”-3期学科建设项目(BMU20100064)
关键词
子宫内膜癌
生活质量
治疗
endometrial cancer
quality of life
treatment
