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Treg/Th17细胞分化失衡与炎症性肠病 被引量：4

Imbalance of Treg/Th17 Cells Differentiation and Inflammatory Bowel Disease
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摘要 炎症性肠病(IBD)的病因和发病机制尚未完全明确,初始CD4^+T细胞分化异常在其发生、发展过程中起重要作用。初始CD4^+T细胞可分化为调节性T细胞(Treg细胞)和Th17细胞,Treg/Th17细胞间的失衡将导致包括IBD在内的多种自身免疫病的发生。初始CD4^+T细胞周围的细胞因子和芳香烃受体对维持该平衡起重要作用。本文就Treg细胞和Th17细胞及其与IBD的关系作一综述。 The etiology and pathogenesis of inflammatory bowel disease（IBD） have not been well clarified,the abnormal differentiation of naive CD4~＋ T cells is believed to play a critical role in the development of IBD.Naive CD4~＋ T cells can differentiate into regulatory T cells（Treg cells） and Th17 cells,the imbalance of Treg/Th17 cells will cause various kinds of autoimmune disease including IBD.Cytokines around the naive CD4~＋ T cells and aryl hydrocarbon receptor play important roles in maintaining the balance.This article reviewed Treg cells,Th17 cells and their relationship with IBD.
作者 邱新运 于成功
机构地区 南京医科大学附属鼓楼临床医学院消化内科 南京大学医学院附属鼓楼医院消化内科
出处 《胃肠病学》 2011年第8期499-502,共4页 Chinese Journal of Gastroenterology
关键词 T淋巴细胞 调节性 T淋巴细胞 辅助诱导 炎症性肠病 细胞因子类 T-Lymphocytes Regulatory T-Lymphocytes Helper-Inducer Inflammatory Bowel Disease Cytokines
分类号 R574 [医药卫生—消化系统]
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参考文献37

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二级参考文献27

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共引文献22

同被引文献78

  • 1张艳丽,黄循铷,王承党.小鼠葡聚糖硫酸钠急性溃疡性结肠炎模型的建立和评价[J].胃肠病学和肝病学杂志,2006,15(2):130-133. 被引量：28
  • 2李毓,骆芳.针灸治疗对溃疡性结肠炎患者细胞因子的影响[J].新疆中医药,2007,25(2):21-23. 被引量：9
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引证文献4

二级引证文献13

胃肠病学
2011年 第8期

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