摘要
背景:有研究表明经典补肾方剂左归丸可用于治疗绝经后女性的骨质疏松。目的:观察骨质疏松性牙周炎大鼠左归丸与雌激素治疗后颌骨结构和骨量的变化。方法:将SD大鼠麻醉下结扎上颌第一磨牙建立牙周炎模型、摘除大鼠卵巢建立骨质疏松模型,去势3个月后分别用左归丸和戊酸雌二醇治疗3个月。结果与结论:左归丸、戊酸雌二醇治疗均能促进大鼠牙槽骨的新生,减轻牙周附着丧失(P<0.05),使破骨细胞数量减少(P<0.05),牙周组织中骨保护素水平升高(P<0.01),降低了血清中的碱性磷酸酶水平(P<0.01)。结果证实,左归丸、戊酸雌二醇在改善骨质疏松性牙周炎大鼠牙槽骨结构的基础上,促使颌骨骨量增加。
BACKGROUND：Studies have shown that the classic kidney-tonifying prescription Zuogui pill can be used for treatment of osteoporosis in post-menopausal women.OBJECTIVE：To observe the changes in maxillary structure and bone mass in osteoporosis rats with experimental periodontitis.METHODS：Sprague-Dawley rat models of periodontitis were established by ligation of maxillary first molar under the anesthesia.Then osteoporosis was induced in these rat models by overiectomy.After 3 months,these rats were treated with Zuogui pill and estradiol valerate for 3 months.RESULTS AND CONCLUSION：Both Zuogui pill and estradiol valerate promoted the neogenesis of alveolar bone,alleviated the inflammatory status of periodontal tissue（P 0.05）,reduced the osteoclasts（P 0.05）,elevated the osteoprotegerin level in the periodontal tissue（P 0.01）,and decreased the serum level of alkaline phosphatase（P 0.01）.These findings suggest that Zuogui pill and estrodiol valerate can improve the structure of alveolar bone and increase maxillary bone mass in osteoporosis rats with experimental periodontitis.
出处
《中国组织工程研究与临床康复》
CAS
CSCD
北大核心
2011年第33期6211-6215,共5页
Journal of Clinical Rehabilitative Tissue Engineering Research
基金
河北省中医药管理局中医药、中西医结合科研计划课题(2009107)资助,课题名称:左归丸对实验性骨质疏松大鼠牙周炎的影响~~
