摘要
目的:研究舒血宁联合小剂量阿司匹林治疗脑出血并发下肢血栓形成的临床疗效。方法:住院经CT、B超证实为脑出血并发下肢血栓形成的患者50例,深静脉血栓(DVT)的临床可能性评估和诊断流程参照《深静脉血栓形成的诊断和治疗指南》。将其随机分为治疗组和对照组,每组各25例。两组患者均根据具体情况给予降压、调脂等治疗。治疗组在给予卧床休息、抬高患肢、止痛、对症等基本治疗的同时,血栓形成满3 d后用10 ml舒血宁加入5%葡萄糖静点,半个月为1个疗程,血栓形成后1周加用小剂量阿司匹林(100 mg/d),无禁忌者长期应用。对照组仅给予卧床休息、抬高下肢、止痛、对症治疗。治疗半个月后分别观察临床症状缓解情况,血栓治疗前后患肢定点测周径变化,深静脉血栓治疗前后下肢彩超示静脉内径患侧与健侧之差的变化,间接反映血流通畅与否。结果:治疗组有效率为100%,与对照组(80%)相比差异有统计学意义(P<0.05),且对照组无完全缓解。治疗组定点测周径患肢与健侧之差,与对照组比较差异有高度统计学意义(P<0.01)。治疗组患者下肢血管患侧与健侧内径之差比较,差异有高度统计学意义(P<0.01)。结论:舒血宁联合小剂量阿司匹林治疗脑出血患者并发血栓形成有较明显的治疗效果。
Objective： To study the clinical effect of Shuxuening combined with small dose of Aspirin on intracerebral hemorrhage complicated by deep vein thrombosis（DVT） of lower limb.Methods： The clinical feasibility evaluation and diagnosis process referred to DVT diagnosis and treatment guidelines.50 cases of intracerebral hemorrhage complicated by DVT of lower limb were diagnosed by CT,B-ultrasound and randomly divided into treatment group（25 cases） and control group（25 cases）.The treatment group was given the treatment as follows： 10 ml Shuxuening Injection were used by intravenous drip,one time a day,15-day-time as a course of treatment when blood clots forming 3 days,small dose of antidepressant（100 mg/d） added when blood clots forming 7 days,no contraindication long-term application,on the foundation of routine therapy of DVT such as bed rest,raising limb,analgesia,and so on.The control group was accepted routine therapy only.The clinical symptom remission,changes in limb circumference detected by sentinel and the diameter changes of Ipsilateral and contralateral of lower limb Doppler ultrasound showed before and after the treatment of DVT were detected after the treatment of half month.Results： There was obvious statistical difference of the clinical symptom remission rate between the treatment group（100%） and the control group was（80%）.Color doppler ultrasound showed that there was obvious statistical difference in limb circumference detected by sentinel between the treatment group and the control group.There was obvious statistical difference in the diameter of Ipsilateral and contralateral of lower limb in the treatment group,and no significant difference in the control group.Conclusion： There is relatively obvious clinical effect of Shuxuening combined with small dose of antidepressant on intracerebral hemorrhage complicated by DVT of lower limb.
出处
《中国医药导报》
CAS
2011年第28期71-73,共3页
China Medical Herald
关键词
阿司匹林
舒血宁
脑出血
深静脉血栓
Aspirin
Shuxuening
Intracerebral hemorrhage
Deep vein thrombosis
