摘要
目的:研究硬骨鱼紧张素ⅡS89N基因(UTS2-S89N)单核苷酸多态性(SNP)与东乡族原发性高血压(EH)患者血脂的关系。方法:采用PCR-RFLP及电泳分析法对东乡族102例健康个体(对照组)及120例EH患者(病例组)进行基因分型;全自动生化仪测定血脂水平;分析各基因型与东乡族人群EH患者血脂水平的关联性。结果:东乡族EH患者的TC、TG和LDL-C均高于对照组(P<0.01)。在病例组患者中,携带SS基因型患者的LDL-C水平(2.76±1.02)mmol·L-1显著高于NN基因型(2.34±0.37)mmol·L-1和NS基因型(2.12±0.65)mmol·L-1差异有统计学意义(P<0.05),而在正常对照组则无此差异。TC、TG和HDL-C水平在病例组与对照组各基因型之间差异均无统计学意义(P>0.05)。结论:UTS2-S89N基因SS基因型与东乡族EH患者血脂水平升高存在关联性。
Objective To study the association between urotensin Ⅱ（UTS2） S89N gene single nucleotide polymorphism（SNP） and serum lipid level in essential hypertension（EH） patients in Dongxiang population.Methods The genotypes of UTS2-S89N of 102 normal persons（control group） and 120 EH patients（case group） were conducted by PCR-RFLP and agarose gel electrophoretic analysis.The serum lipid levels was detected by automatic biochemical analyzer.The association between genotypes of UTS2-S89N and the serum lipid level in Dongxiang population was analyzed.Results The levels of TC,TG,and LDL-C in case group.were higher than those in control group（P0.01）.In case group,the level of LDL-C of the patients with SS gentype（2.76±1.02） was higher than those of the patients with NN genotype（2.34±0.37） and NS genotype（2.12±0.65）（P0.05）.The levels of TC,TG and HDC-C had no significnat differences between various genotypes in two groups（P0.05）.Conclusion The SS genotype of UTS2-S89N gene is associated with the serum lipid of the EH patients in Dongxiang population.
出处
《吉林大学学报（医学版）》
CAS
CSCD
北大核心
2011年第5期890-893,共4页
Journal of Jilin University：Medicine Edition
基金
甘肃省科技厅自然科学基金资助课题(1010RJZA158)
关键词
东乡族
血脂
原发性高血压
单核苷酸多态性
硬骨鱼紧张素Ⅱ基因
Dongxiang population
serum lipid
essential hypertension
single nucleotide polymorphism
urotensin Ⅱ gene
