摘要
目的探讨重危住院患者抗生素相关性腹泻(antibiotic associated diarrhea,AAD)的发病率、临床特点及防治措施。方法对某院2007年1月—2010年12月间的住院患者进行回顾性调查分析。结果使用抗生素的4431例患者有174例发生AAD,发病率为3.93%,AAD的发生与患者高龄、基础疾病严重情况、抗生素使用种类、联合用药数量及疗程等因素相关。所有AAD患者经停用或换用抗生素、服用微生态制剂,加强支持治疗后均好转。结论 AAD是一种常见的抗生素治疗的并发症,在重危患者中发病率较高,合理使用抗生素,严格控制广谱抗生素的使用,是预防控制AAD的关键。
Obiective To study the incidence, the clinical characteristics, prevention and therapeutic measure of the antibiotic associated diarrhea （AAD）. Methods To measure retrospectively and prospective the hospitalized intensive care patients in our department wards during Jan., 2007 to Dec., 2010. Results 174 patients using antibiotics resulted in AAD, prevalence ratio 3.93%, and the factors were related to the elderly, the grievours degree of deseases, the kinds of using mix antibiotics and period of treatment. All the patients were improved by reducing or replacement of the antibiotic, taking microorganism preparation, and strengthening sustain treatment. Conclusion AAD is a frequent complication of antibiotic therapy, the incidence is relatively higher in the serious cases. Prognosis of most patients is good under proper management. It was the key management of preventing and controlling AAD that appropriate antibiotic practice was aware and broad-spectrum antibiotic was strictly controlled.
出处
《中国抗生素杂志》
CAS
CSCD
北大核心
2011年第10期790-792,共3页
Chinese Journal of Antibiotics
关键词
抗生素相关性腹泻
重危病人
临床特征
Antibiotic associated diarrhea
Intensive care patients
Clinical characteristic
