摘要
目的探讨功能性消化不良(FD)患儿胃黏膜肥大细胞(MC)的密度及其活化状态与胃排空的关系。方法按罗马Ⅱ标准选择FD患儿40例,每例患儿均取胃窦黏膜1块,应用免疫组织化学法检测其MC数及其脱颗粒数,然后行固体胃排空检测,固体胃排空正常患儿为胃排空正常组,其他患儿为胃排空延迟组;统计所有标本MC的密度及脱颗粒程度,比较二组患儿的MC密度及活化状态的差异,比较MC密度正常患儿与异常患儿的胃排空差异,评估MC的脱颗粒指数与胃排空间的关系,最后进行胃排空与MC密度及脱颗粒指数间的相关性分析。结果 1.FD患儿的胃黏膜MC脱颗粒指数为(65.7±23.9)%,其中>50%者占82.5%;2.与1 h胃排空正常组相比,1 h胃排空延迟组MC密度显著升高(P=0.010);3.与MC密度正常组相比,MC密度异常组1 h胃排空明显延迟(P=0.001);4.MC脱颗粒指数与胃排空无明显关系;5.MC密度与1 h胃排空率呈负相关(P=0.030)。结论 FD患儿的胃排空延迟与MC密度升高有关,MC可能通过影响胃排空介导儿童FD的发生和发展。
Objective To investigate the correlations of gastric mucosa mast cells （MC） density and activation states with gastric emptying in children with functional dyspepsia（FD）. Methods Forty pediatric patients diagnosed as FD according to Rome II criteria were recruited in this study. After an antral biopsy was obtained for calculating the amount and degranulation index of MC ,the gastric emptying was detected for each patient. Statistical analysis was used to evaluate the density and the degranulation degrees of MC,then the MC density and its activation state between normal and abnormal gastric emptying groups were compared, and the gastric emptying between normal and abnormal MC density groups were compared,and the correlation of MC degranulation index was evaluated with gastric emptying. And then, interactions of MC density and activation states with gastric emptying were analyzed. Results 1. With a mean of（65.7 ± 23.9 ） %, MC degranulation index 〉 50% was in 82.5% patients. 2. Compared with normal gastric emptying group, MC density had been found to be increased in patients with delayed gastric emptying at 1 hour（ P = 0. 010）. 3. Gastric emptying had delayed in patients with increased MC density （ P = 0. 001 ）. 4. MC degranulation index wasn＇t correlated with gastric emptying. 5. Elevated mean MC density was associated with delayed gastric emptying at 1 hour （ P = 0.030）. Conclusions There is association of delayed gastric emptying with elevating MC density in children FD, and MC mediated generation and development of FD through influencing gastric emptying.
出处
《实用儿科临床杂志》
CAS
CSCD
北大核心
2011年第19期1503-1505,共3页
Journal of Applied Clinical Pediatrics
关键词
功能性消化不良
胃黏膜
肥大细胞
胃排空
儿童
functional dyspepsia
gastric mucosa
mast cell
gastric emptying
child
