摘要
目的探讨全血细胞减少症(IR P)中B淋巴细胞及C D 5+B数量检测的临床意义。方法采用流式细胞术对IRP初诊组(n=24),完全缓解组(n=17)和正常对照组(n=20)骨髓总B淋巴细胞、CD 5+B淋巴细胞的数量。结果 IRP初诊组患者总B淋巴细胞、CD 5+B淋巴细胞比例为(8.24±4.55)%和(20.83±11.40)%,显著高于完全缓解组的(2.85±1.61)%和(12.36±10.27)%以及正常对照组的(2.97±1.43)%和(12.15±6.14)%,差异有统计学意义(P<0.05);而完全缓解组和正常对照组骨髓总B淋巴细胞、C D 5+B淋巴细胞的数量差异无统计学意义(P>0.05)。结论 IR P患者自身抗体的产生可能与B淋巴细胞及其亚群数量异常有关。流式细胞术为IR P鉴别诊断提供了可靠的检测手段。
【Objective】 To explore clinical significance of the quantity of B lymphocyte and CD5＋B in the patients with immunorelated pancytopenia（IRP） and explore the role of B lymphocyte in the pathogenetic mechanism of IRP.【Methods】 Quantities of all B lymphocytes and CD5＋B lymphocytes in 24 patients with untreated IRP,17 IRP patients in complete remission（CR） and 20 normal controls were assayed by FCM.【Results】 The percentages of B lymphocyte and CD5＋B lymphocytes were significantly higher in untreated group than those in CR group and normal controls group（P 0.05）;there was no significant difference between the latter two groups（P 0.05）.【Conclusion】 The production of auto-antibodies in IRP patients probably has some relationships with the abnormal quantities of B lymphocyte and its subset.
出处
《中国现代医学杂志》
CAS
CSCD
北大核心
2011年第25期3140-3142,共3页
China Journal of Modern Medicine
