摘要
目的系统评价黄芪注射液+雄激素与雄激素单用比较治疗再生障碍性贫血(再障)的疗效和安全性。方法计算机检索Cochrane Library(2011年第3期)、PubMed(1966～2011.3)、EMbase(1974～2011.3)、CNKI(1994～2011.3)、VIP(1989～2011.3)和万方(1997～2011.3)数据库等,按照纳入排除标准选择文献、提取资料和进行质量评价后,采用RevMan 5.0.24软件进行Meta分析。结果共纳入7个随机对照试验,合计518例患者。Meta分析结果显示:黄芪注射液+雄激素治疗组的总有效率优于单用雄激素组,其差异有统计学意义[OR=3.12,95%CI(2.09,4.66),P<0.00001];治疗组与对照组的骨髓增生升级程度相当,其差异无统计学意义[OR=1.93,95%CI(0.85,4.38),P=0.11];治疗组的不良反应明显少于对照组,其差异亦有统计学意义[OR=0.30,95%CI(0.12,0.76),P=0.01]。结论黄芪注射液+雄激素治疗再障的有效率高于单用雄激素,且不良反应少。但由于纳入研究样本量小且质量较低,上述结论尚需更多高质量的研究来加以证实。
Objective To assess the clinical effectiveness and safety of astragalus injection plus androgen versus androgen alone for patients with aplastic anemia（AA）.Methods Such databases as The Cochrane Library（Issue 3,2011）,PubMed（1966 to March 2011）,EMbase（1974 to March 2011）,CNKI（1994 to March 2011）,VIP（1989 to March 2011） and Wanfang Data（1997 to March 2011） were searched to include the randomized controlled trails（RCTs） according to the inclusive and exclusive criteria.The data were extracted,the quality was assessed,and meta-analysis was conducted by using Revman5.0.24 software.Results Seven RCTs involving 518 patients with AA were included.The meta-analysis showed that the astragalus plus androgen treatment group was superior to the androgen alone group in the total effective rate with significant difference（OR=3.12,95%CI 2.09 to 4.66,P0.000 01）;the adverse events in the treatment group were fewer than those in the control group with significant difference（OR=0.30,95%CI 0.12 to 0.76,P=0.01）;but the promotion degree of myelosis between the two groups was similar without significant difference（OR=1.93,95%CI 0.85 to 4.38,P=0.11）.Conclusion The astragalus plus androgen treatment is superior to the androgen alone treatment in the total effective rate and fewer adverse events.More high-quality trails are required to verify this conclusion due to the low quality and small scale of the included studies.
出处
《中国循证医学杂志》
CSCD
2011年第10期1205-1209,共5页
Chinese Journal of Evidence-based Medicine
关键词
黄芪
雄激素
再生障碍性贫血
系统评价
META分析
随机对照试验
Astragalus injection
Androgen
Aplastic anemia
Systematic review
Meta-analysis
Randomized controlled trial
