摘要
[目的]观察肾炎宁胶囊对慢性肾炎气虚湿瘀型患者蛋白尿的影响.[方法]慢性肾炎气虚湿瘀型共60例,随机分为试验组和对照组,每组30例,试验组口服肾炎宁胶囊,4粒/每次,1日3次;对照组口服肾炎康复片,5片/每次,1日3次.3个月为一疗程.比较两组治疗前后尿蛋白的定量检测以及患者症状（浮肿,腰酸,乏力,纳差等）变化.[结果]两组经治疗后蛋白尿定量均有降低.试验组完全缓解率为50.0%,完全缓解加基本缓解率90.0%,总有效率90.0%;而对照组完全缓解率为23.3%,完全缓解加基本缓解率56.7%,总有效率为83.3%.两组总有效率比较无统计学差异（χ2=0.5769,P＞0.05）,但完全缓解率比较有统计学差异（χ2= 4.5933,P＜0.05）,完全缓解加基本缓解率比较有明显的统计学差异（χ2= 8.5227,P＜0.01）.[结论]肾炎宁胶囊具有明显降低慢性肾炎气虚湿瘀型尿蛋白排泄量,改善浮肿,腰酸,乏力,纳差等气虚湿瘀证候的作用.
[Objective] To observe the effect of Shenyanning capsules on proteinuria in patients with chronic glomerulonephritis with Qi-deficiency, damp and blood-stasis syndrome. [Methods] Sixty patients were randomly assigned into experiment group and control group with 30 patients in each. The experiment group took oral Shenyanning capsules with four pills each time for three times a day, while the control group took oral Shenyankangfu tablets with 5 tablets each time for three times a day. The treatment course was 3 months. The quantitative detection of urine protein and the symptoms of patients including edema, lumbago, fatigue and anorexia were compared between before and after treatment. [Results] Urine protein quantitation in two groups decreased after treatment. The complete remission rate of the experiment group was 50.0%, and the total rate of complete remission plus basic remission was 90.0%, and the total effective rate was 90%. The complete remission rate of control group was 23.3%, and the total rate of complete remission plus basic remission was 56.7 %, and the total effective rate was 83.3 %. There was no significant difference in the total effective rate between two groups（X^2：0. 5769, P〉0.05）, but there was significant difference in the complete remission rate between two groups （X^2=4. 5933, P〈0.05）, and there was also significant difference in the total rate of complete remission plus basic remission（x^2= 8. 5227, P〈0.01）. [Conclusion] Shenyanning capsules can significantly reduce the proteinuria excretion of chronic glomerulonephritis with Qi deficiency, damp and blood- stasis syndrome, and improve the clinical symptoms including edema, lumbago,fatigue, anorexia and so on.
出处
《医学临床研究》
CAS
2011年第9期1698-1700,共3页
Journal of Clinical Research
