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结直肠息肉、腺瘤及腺癌中间质细胞CD34和α-SMA的表达及其意义 被引量：2

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摘要 目的探讨CD34和平滑肌肌动蛋白(α-SMA)在结直肠息肉、腺瘤及腺癌中的诊断价值。方法应用免疫组化SP法检测正常组织、息肉、腺瘤及腺癌各40例中的间质细胞CD34、α-SMA的表达。结果 CD34在正常组织中高表达,在腺癌中低表达,差异有统计学意义;CD34在息肉中的表达比在腺癌中表达要高,两者差异有统计学意义;而正常与息肉、息肉与腺瘤以及腺瘤与腺癌之间比较差异无统计学意义;α-SMA在正常组织中低表达,在腺癌中高表达,两者比较差异有统计学意义;另外α-SMA正常组织与息肉及正常组织与腺瘤中的表达差异均具有统计学意义;α-SMA在息肉和腺癌中的表达差异有统计学意义,而α-SMA在息肉和腺瘤及腺瘤和腺癌中的表达差异无统计学意义。结论在结直肠息肉、腺瘤和腺癌病变中表现为CD34表达缺失而α-SMA表达获得;检测结直肠标本中间质细胞CD34和α-SMA的表达有助于帮助病理诊断以及对病变的转化有一定的提示作用。
作者 韦康来 梁秀就 冯振博
机构地区 广西医科大学第一附属医院病理科
出处 《广东医学》 CAS CSCD 北大核心 2011年第19期2534-2535,共2页 Guangdong Medical Journal
关键词 结直肠 息肉 腺瘤 腺癌 间质细胞 CD34 Α-SMA
分类号 R692.3 [医药卫生—泌尿科学]
  • 相关文献

参考文献8

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二级参考文献33

共引文献16

同被引文献20

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引证文献2

二级引证文献7

广东医学
2011年 第19期

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