摘要
目的探讨凋亡相关因子Cyt-c、Bax、Bcl-2蛋白在卵巢上皮性肿瘤中的表达及意义。方法应用免疫组织化学SP法及Image-ProPlus图像分析软件检测Cyt-c、Bax、Bcl-2蛋白在15例正常卵巢组织、15例卵巢上皮性良性肿瘤、15例卵巢上皮性交界性肿瘤及30例原发性上皮性卵巢癌中的表达情况。结果 Cyt-c、Bax、Bcl-2在恶性组中的阳性表达显著高于其它三组。Cyt-c蛋白表达与临床分期及淋巴结转移有关,Bax、Bcl-2蛋白表达与临床分期有关。Bax与Bcl-2在上皮性卵巢癌中的表达呈负相关。结论 Cyt-c、Bax、Bcl-2与上皮性卵巢癌的发生有关;Cyt-c、Bcl-2的高表达提示预后不良。
Objective To investigate the expression and significance of Cyt-c,Bax,Bcl-2 protein of Apoptosis Related Regulation Factors in epithelial ovarian tumors.Methods Expressions of Cyt-c,Bax and Bcl-2 were detected by IHC and Image-ProPlus image analysis software in 15 cases of normal epithelial ovarian tissues,15 cases of ovarian benign tumor,15 cases of borderline ovarian tumors and 30 cases of primary epithelial ovarian cancer.Results The positive expressions of Cyt-c,Bax,Bcl-2 in the malignant group was significantly higher than the other three groups.The expression of Cyt-c was related with clinical stage and lymph node metastasis,The expression of Bax,Bcl-2 were related with clinical stage.Bax and Bcl-2 in epithelial ovarian carcinoma were negatively correlated.Conclusion Cyt-c,Bax,Bcl-2 were related with the occurrence of epithelial ovarian cancer;The high expressions of Cyt-c,Bcl-2 indicates a poor prognosis.
出处
《遵义医学院学报》
2011年第4期357-360,共4页
Journal of Zunyi Medical University
