摘要
本文观察了莨菪类药物(东茛菪碱、樟柳碱、山茛菪碱)对大鼠三种实验性胃溃疡的影响,并对其作用机制进行了初步的探讨。结果表明:莨菪类药物有对抗大鼠应激性胃溃疡、药物性胃溃疡及慢性胃溃疡的作用,且有量效依赖关系;对胃液和血液等各项生化指标分析表明,这类药物有抑制胃酸分泌、降低胃蛋白酶活性、增强胃粘液屏障,提高血清胃泌素浓度的作用。提示这些结果可能与其抗溃疡效应有关。
In the present paper, effects of scopolia drugs(scopolamine, anisodine, anisodamine) on experimental gastric mucosal lesion models inrats were investigated.
Scopolia drugs were found to be effective anti-ulcer agents in three experimental gastric ulcer models (i.e.cold-restraint stress induced ulcer, indomethacin induced ulcer and acetic acid induced chronic ulcer) in rats in a dose dependent manner.
Biochemical analysis of gastric juice and blood showed that scopolia drugs could inhibit gastric acid secretion and pepsin activity, increase gastric barrier mucus and concentration of serum gastrin, suggesting that these actions may contribute to its anti-ulcer effect.
出处
《药学学报》
CAS
CSCD
北大核心
1990年第2期90-94,共5页
Acta Pharmaceutica Sinica
关键词
莨菪类药物
抗溃疡药
胃溃疡
Scopolia drug
Antiulcer agent
Gastric ulcer
