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电针对AD大鼠学习记忆及神经干细胞表达的影响 被引量:1

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摘要 目的:探讨电针对老年痴呆大鼠学习记忆功能和神经干细胞的巢蛋白(Nestin)、碱性成纤维细胞生长因子 (bFGF)表达的影响。方法:成年Wistar雄性大鼠随机分为正常组、模型对照组、模型组、西药组、电针组,每组12只。链脲霉素(STZ)注射法造大鼠AD模型.电针治疗三个疗程。Morris水迷宫测试大鼠学习记忆能力,免疫组化检测Nestin和bFGF表达。结果:定位航行试验显示,平均逃避潜伏期比较,AD模型组明显长于正常组、模型对照组,治疗后西药组、电针组有提高(P〈0.05, .电针组大鼠海马的Nestin和bFGF)阳性细胞数目最多,与模型组相比,差异具有显著性(P〈0.05)。结论:电针能够显著增强痴呆大鼠学习记忆功能, 修复AD大鼠的神经缺损,实现神经的保护效应。
出处 《中国中医药咨讯》 2011年第20期45-45,111,共2页
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