摘要
目的对比复方甘草酸苷与强的松治疗扁平苔藓的临床疗效、复发情况和不良反应。方法选择51例临床诊断为扁平苔藓的患者,随机分为治疗组和对照组,治疗组25例口服复方甘草酸苷胶囊3次/d,每次2粒,罗红霉素150 mg,2次/d,氯雷他定片10 mg,1次/d,皮损部位外用皮质激素软膏,口腔部位外用锡类散,症状缓解后复方甘草酸苷逐渐减量至停药,疗程共4周;对照组26例口服强的松10 mg,3次/d,其余治疗与对照组相同,症状缓解后强的松逐渐减量至停药,疗程共4周,疗程结束后评估疗效。结果治疗组有效率为88%,对照组有效率为92.31%,两者差异无显著性(P>0.05);治疗组的总复发率为28%,对照组的总复发率为53.85%,两者差异有显著性(P<0.05);治疗组副反应发生率为8%,对照组副反应发生率为30.77%,治疗组的副反应发生率明显低于对照组。结论复方甘草酸苷是一种治疗扁平苔藓疗效肯定、安全理想的药物。
Objective Compare the glycyrrhizin with prednisone treatment of lichen planus about clinical efficacy and adverse reactions.Methods 50 cases diagnosed as lichen planus were randomly divided into treatment group and control group.Treatment group,25 cases to oral glycyrrhizin capsule 3 times a day,once 2 capsules,roxithromycin 150mg,twice a day,loratadine tablets 10mg,once a day.Topical skin lesions use corticosteroid ointment,Oral topical part use Xileisan.After the symptoms ease glycyrrhizin was gradually tapered to withdrawal,total course of 4 weeks;The control group of 26 cases oral prednisolone 10mg,3 times a day.The rest treatment was the same as control group,After the symptoms ease,prednisone was gradually tapered to withdrawal,total course of 4 weeks.Assess the efficacy.after entire treatment.Results The efficacy of the treatment group was 88% while in the control group it was 92.31%.There′s no significant difference（P0.05）;Total recrudescent rate of treatment group was 28%,while it of control group was 53.85%.There′s significant difference（P0.05）.The adverse reactions in treatment group was 8%,while side effects occurred in control group was 30.77%.The figue showes side effects in treatment group were significantly lower than that in control group.Conclusion Glycyrrhizin is an effective,safe and ideal drug of lichen planus.
出处
《黑龙江医学》
2011年第9期689-691,共3页
Heilongjiang Medical Journal
