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牛痘疫苗接种家兔炎症皮肤提取物联合神经阻滞治疗肿瘤相关性周围神经病的疗效 被引量:5

EFFICACY OF NEUROTROPIN COMBINED WITH NERVE BLOCK FOR PATIENTS WITH TUMOR-ASSOCIATED PERIPHERAL NEUROPATHY
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摘要 目的:观察牛痘疫苗接种家兔炎症皮肤提取物神经妥乐平(NTP)联合神经阻滞治疗肿瘤相关性周围神经病的临床疗效。方法:44例患肿瘤或与肿瘤相关的治疗后有周围神经病变患者,随机分为NTP联合相关部位神经阻滞治疗组(联合组)与单纯神经阻滞组(阻滞组),每组22例。分别给予静脉NTP注射液7.2单位+0.9%NS 100ml,日一次静滴,配合神经阻滞(0.5%利多卡因+弥可保1.0mg镇痛复合液每部位5ml,首次应用曲安奈德10mg)连续应用15天为一疗程。观察治疗后7天、15天、30天VAS评分(视觉模拟评分法,visual analogue scale)、镇痛效果、治疗前后观察疼痛、麻木、感觉减退、感觉过敏等指标的改善情况。结果:联合组治疗前VAS为(8.01±1.15)分,治疗后为(1.89±0.41)分,治疗前后比较差异有统计学意义(P<0.01);联合组的改善率分别为87.5%(痛觉)、84.2%(麻木)而阻滞组改善率为33.3%(痛觉)、68.4%(麻木)。疼痛与麻木和阻滞组相比,差异有统计学意义(P<0.05)。联合组总有效率在治疗4周时为90.9%,阻滞组为68.1%,组间比较分析差异有显著意义(P<0.01)。结论:NTP联合神经阻滞治疗肿瘤相关性周围神经病疗效显著,有效地改善患者的疼痛、麻木、感觉减退、感觉过敏,显著优于单纯神经阻滞组。 Objective: To observe clinical efficacy of Neurotropin(Neurotropin-NTP,inflammatory rabb-it skin inoculated with vaccinia virus extract injection) combined with nerve block therapy in tumor-ass-ociated peripheral neuropathy.Methods: 44 canaer patients with tumors-related or therapeutic-related pe-ripheral neuropathy were randomly divided into NTP combined nerve block group(Combined group) and nerve block alone group(Block group);each group contains 22 cases.NTP 7.2 units were given intraveno-usly + 0.9% NS 100ml QD,combined with the nerve block(0.5% lidocaine + methylcobalamin 1.0 mg 5ml per site,and triamcinolone acetonide 10mg was given at the frist time) for 15 d.Assessments were made before and 7,15 and 30 d after treatment,including VAS score(visual analog scale) on analgesic effect,numbness,hypoesthesia,hyperesthesia,and other indicators.Results: Visual analog scale(VAS) was 8.01 ± 1.15 before treatment,and 1.89 ± 0.41 after treatment(P〈0.01).The improvement of Neur-otropin group was 87.5%(pain) and 84.2%(numbness),while in the block group was only 33.3%(pain) and 68.4%(numb),respectively.(P〈0.05).Total effective rate in the end of 4 weeks was 90.9% in Neurotropin group and 68.1% in block group(P〈0.01).Conclusion : In patients with tumor-associated peripheral neuropathy,NTP combined with nerve block is effective in improving the patient's pain,numb-ness,hypoesthesia,hyperesthesia,and minor side effects,which is significantly better than the nerve block group.
出处 《中国疼痛医学杂志》 CAS CSCD 2011年第10期607-610,共4页 Chinese Journal of Pain Medicine
关键词 神经妥乐平 神经阻滞 肿瘤相关性 周围神经病 Inflammatory rabbit skin inoculated with vaccinia virus extract injection Nerve block Tum-or-related Peripheral europathy
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