摘要
目的:对比观察帕洛诺司琼和恩丹西酮预防化疗诱发恶心和呕吐的作用及其不良反应。方法:采用随机自身对照方法对36例接受中～高度致吐化疗药物的恶性肿瘤患者使用帕洛诺司琼进行止吐治疗,并与恩丹西酮作对照,于化疗第1个周期或第2个周期使用帕洛诺司琼止吐,同一患者于另1个周期使用恩丹西酮作自身对照。结果:帕洛诺司琼于急性呕吐期(化疗后24h内)止吐完全有效率为94.4%,恩丹西酮组为83.3%,帕洛诺司琼控制急性呕吐的疗效优于恩丹西酮,但两组比较差异无统计学意义,P>0.05。帕洛诺司琼于延迟呕吐期(化疗后d2～d5)止吐的有效率(完全有效率+部分有效率)均高于恩丹西酮,但两组差异均无统计学意义,P>0.05。帕洛诺司琼的不良反应主要为头痛和便秘,与恩丹西酮比较,两组主要不良反应发生率差异无统计学意义,P>0.05。结论:帕洛诺司琼能有效预防中、高度致吐化疗药物所致的恶心和呕吐反应,对于急性和延迟性呕吐反应相比恩丹西酮有较好疗效。
OBJECTIVE： To evaluate the effect and toxicity of palonosetron in preventing chemotherapy-induced nausea and vomiting.METHODS： Thirty-six patients undergoing high and moderate emetic risk chemotherapy received palonosetron to control emesis.Ondansetron was used as self-control in the previous or next course of the chemotherapy in the same patient.RESUTSLS： The effective rate of acute（during the first 24 hours） nausea and vomiting in palonosetron group and in ondansetron group are 94.4% and 83.3% respectively.But there was no significant difference between these two drugs.The effective rates of delayed（day 2 to day 5 after chemotherapy） nausea and vomiting in palonosetron group were higher than in ondansetron group.Similarly,there were no significant differences between the effect rates of these two drugs.The toxicities of palonosetron were headache and constipation.The differences between the incidences of main toxicities had no statistic significant for both drugs.CONCLUSION： Palonosetron is effective and safe in controlling of acute and delayed nausea and vomiting induced by high and moderate emetic risk chemotherapy.
出处
《中华肿瘤防治杂志》
CAS
2011年第16期1296-1298,共3页
Chinese Journal of Cancer Prevention and Treatment
