摘要
目的:探讨了慢性丙型肝炎患者血浆内毒素和血清甘露聚糖结合凝集素(MBL)水平的变化及意义。方法:应用鲎试验和酶联法对31例慢性丙型肝炎患者进行了血浆内毒素和血清MBL测定,并与35名正常健康人作比较。结果:慢性丙型肝炎患者血浆内毒素和血清MBL水平均非常显著地高于正常人水平(P<0.01),且内毒素水平与MBL呈正相关(r=0.4784,P<0.01)。结论:血浆内毒素和血清MBL可反映HCV感染导致慢性病理状态,它可能也参与肝脏纤维化的过程。
Objective To explore the changes and significance of plasma endotoxin and serum mannan-binding lectin（MBL） levels in patients with hepatitis C.Methods Plasma endotoxin（with limulus test） serum MBL（with ELISA） levels were measured in 31 patients with hepatitis C and 35 normal controls.Results plasma endotoxin and MBL levels were extremely higher than those in controls（P0.01）.Plasma endotoxin level was positive correlations with MBL levels（r=0.4784,P0.01）.Conclusion Detection of plasma endotoxin and MBL levels domonstrate that HCV infection resulted in chronic pathologic process suggesting it possibly play a role in the development of fibrosis in hepatitis C virus-infected patients.
出处
《放射免疫学杂志》
CAS
2011年第5期556-557,共2页
Journal of Radioimmanology
