摘要
目的探讨血必净注射液对急性百草枯（PQ）中毒患者的多器官保护作用。方法选择本院2005年1月至2010年12月急性PQ中毒患者35例为研究对象，随机分为治疗组（18例）和对照组（17例）。对照组给予常规治疗，治疗组在对照组治疗的基础上应用血必净注射液50ml静脉滴注，每日2次，连用1周。检测两组患者动脉血氧饱和度（SaO2）、血浆丙二醛（MDA）、超氧化物歧化酶（SOD）水平，以及各器官的生化指标变化和病死率。结果治疗组患者治疗3d时SaO2高于对照组（0．85±0．08比0．74±0．06，P〈0．05），治疗7、14、21d时Sa02高于对照组的趋势就更明显（7d：0．74±0．09比0．54±0．03，14d：0．66±0．11比0．48±0．02，21d：0．62±0．14比0．36±0．05，均P〈0．01）；治疗组3d、7d时血浆MDA水平（μmol／L）低于对照组（3d：6．2±1．1比7．9±1．2，7d：5．6±0．9比6．8±1．3，均P〈0．05）；治疗组治疗3、7、14d时血浆s0D（kU／L）水平均较对照组升高（3d：120．5±8．2比107．3±8．3，7d：129．3±9．5比111．7±8．7，14d：137．0±8．4比120．9±8．6，P〈0．05或P〈0．01）。治疗组病死率明显低于对照组（44．4％比70．6％，P〈0．05）；且治疗组器官损害数、损害程度均轻于对照组，两组比较差异有统计学意义（P〈0．05或P〈0．01）。结论血必净注射液可通过提高机体抗氧化能力，抑制脂质过氧化反应，减少器官功能衰竭，对急性PQ中毒有一定治疗作用。
Objective To investigate the protective effects of Xuebijing injection （ 血必净注射液） on multiple organs for patients with acute paraquat poisoning （PQ）. Methods Thirty-five patients with paraquat poisoning admitted in January 2005 to December 2010 were randomly divided into treatment group （18 patients） and control group （17 patients）. The control group received conventional therapy, and the treatment group, besides the above therapy for control group,was additionally treated by xuehijing 50 ml intravenous drip, twice per day for one week. The levels of arterial oxygen saturation （SaO2）, malondialdehyde （MDA） and superoxide dismutase （SOD） in plasma, the changes of biochemical indexes of multiple organs injury and mortality in the two groups were detected. Results After 3 days of treatment, SaO2 in treatment group was higher than that in control group （0. 85520.08 vs. 0.74±0.06, P〈0. 05）, and the trend of increase was even more obvious after 7, 14, 21 days of treatment （7 days： 0.74±0. 09 vs. 0. 54± 0.03, 14 days： 0.66±0.11 vs. 0.48±0.02, 21 days： 0.622k0.14 vs. 0.36±0.05, all P〈0.01）. The plasma level of MDA （μmol/L） in treatment group was lower than that in control group after 3 days and 7 days of treatment （3 days： 6.2±1.1 vs. 7.9d21.2, 7 days： 5.6±0. 9 vs. 6.8±1.3, both P〈0. 05）. The plasma level of SOD （kU/L） in treatment group was higher than that in control group after 3, 7 and 14 days （3 days： 120. 5±8.2 vs. 107.3±8.3, 7 days： 129.3±9.5 vs. 111.7±8.7, 14 days： 137.0±8.4 vs. 120.9± 8.6, P〈0.05 or P〈0.01）. In treatment group, the mortality rate was lower than that of control group （44.4% vs. 70. 6%, P〈0. 05）, and the number of visceral damage and the degree of damage were lower or milder than those of control group, the differences between the two groups being statistically significant （P〈 0.05 or P〈0.01）. Conclusion Xuebijing injection can be adopted to elevate the ability of anti-oxidation of the organism, inhibit lipid peroxidation and lessen the occurrence of organ functional failure, thus it has a certain therapeutic effect for treatment of acute paraquat poisoning.
出处
《中国中西医结合急救杂志》
CAS
北大核心
2011年第5期296-298,共3页
Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care
关键词
百草枯
中毒
血必净注射液
氧自由基
中西医结合疗法
Paraquat
Poisoning
Xuebijing injection
Oxygen free radical
Combined treatment of traditional Chinese and western medicine
