摘要
目的了解本院鲍曼不动杆菌的临床分布及耐药性变迁情况。方法回顾性分析1999年1月至2010年12月本院临床标本中分离的鲍曼不动杆菌的临床感染特点及其药敏结果;用API鉴定系统及VITEK2系统进行细菌鉴定;用K-B纸片扩散法进行药敏试验;用WHONET5.4软件分析鲍曼不动杆菌的耐药性。结果鲍曼不动杆菌的临床分离率及对临床常用的19种抗菌药物耐药率,总体呈上升趋势;其感染主要发生在重症监护病房(ICU)和呼吸内科;鲍曼不动杆菌的多重耐药和泛耐药也同样主要分布在这2个病区;检出菌株数最多的标本是痰;年龄越大检出率越高。结论鲍曼不动杆菌的耐药形势严峻,其分离率和耐药率呈逐年上升趋势,其多重耐药和泛耐药比例明显增加。
Objective To understand the distribution characteristics and drug resistance of Acinetobacter baumannii in clinical specimens.Methods The result of drug susceptibility and clinical distribution of Acinetobacter baumannii from Jan 1999 to Dec 2010 in our hospital were analyzed and studied retrospectively.Acinetobacter baumannii was identified by API and VITEK2 system,and its antimicrobial resistance was determined by Kirby-Bauer method.The antimicrobial resistance rates were analyzed by WHONET 5.4 software.Results The isolation rate and the resistance rate of Acinetobacter baumannii to 19 kinds of drugs appeared increasing trend during from 1999 to 2010.Acinetobacter baumannii strains were mainly distributed at ICU wards and respiratory department,the same as the multi-drug resistance and pan-drug resistance strains.The major strains was isolated from sputum,the older the age,the higher the appearing rate.Conclusion Acinetobacter baumannii has severe drug resistance,the isolation rate of Acinetobacter baumannii is increasing and the resistance rate to drugs appears increasing trend,the number of multi-drug resistant and pan-drug resistant Acinetobacter baumannii had been increased sharply.we should enhance to this kind of isolates detection,control the A.baumannii colonization and spread in hospital in order to prevent the outbreak and epidemic of nosocomial infections.
出处
《中国临床药理学杂志》
CAS
CSCD
北大核心
2011年第10期755-758,共4页
The Chinese Journal of Clinical Pharmacology
关键词
鲍曼不动杆菌
抗菌药物
耐药性
Acinetobacter baumannii
antimicrobial agent
drug resistance
