摘要
目的探讨针刺背俞穴加刺络拔罐治疗慢性荨麻疹的临床疗效及作用机制。方法选取64例慢性荨麻疹患者为研究对象,同时选择正常健康体检者30例作为健康组。治疗组32例采用针刺背俞穴加刺络拔罐治疗,对照组32例采用口服西替利嗪治疗,观察两组患者的临床疗效及治疗前后血清白细胞介素4(IL-4)、γ干扰素(IFN-γ)和免疫球蛋白E(IgE)的变化。健康组不给予任何治疗,只进行1次免疫指标的检测。结果治疗组痊愈18例(56.25%),显效9例(28.12%),有效3例(9.38%),无效2例(6.25%),总有效率93.75%;对照组痊愈8例(25.00%),显效12例(37.50%),有效5例(15.62%),无效7例(21.88%),总有效率78.12%。两组患者疗效间差异有统计学意义(P<0.05)。治疗前,治疗组、对照组与健康组比较,患者血清IFN-γ水平明显降低,IL-4和IgE水平明显升高,差异均有统计学意义(P<0.05),治疗组与对照组比较三项指标差异均无统计学意义(P>0.05);治疗后,治疗组中血清IFN-γ水平明显上升,IL-4和IgE水平明显下降,治疗组与对照组治疗前后三项指标差值比较,差异均有统计学意义(P<0.05)。结论针刺背俞穴加刺络拔罐疗法通过提高血清IFN-γ水平、降低IL-4水平,纠正患者Thl、Th2淋巴细胞的平衡失调;降低IgE水平,达到减少细胞递质释放、降低血管通透性的目的 ,从而实现对慢性荨麻疹的有效治疗,是临床上治疗慢性荨麻疹的较好的方法。
Objective To explore the clinical effects and mechanisms of back-shu point acupuncture combined with pricking and cupping therapy in treating chronic urticaria. Methods A total of 64 chronic urticaria patients and 30 health subjects（healthy group） were enrolled.Thirty-two patients underwent back-shu point acupuncture combined with pricking and cupping therapy（treatment group） and another 32 patients were treated by oral Cetirizine（control group）.The healthy group received no treatment but immunological test for once.Clinical curative effects and serum levels of IL-4,IFN-γand IgE before and after treatment were compared between the two patient groups. Results In the treatment group,total effective rate was 93.75%;18 cases（56.25%） recovered,9 cases（28.12%） were notably effective,3 cases（9.38%） were effective,and the procedure was invalid in 2 cases（6.25%）.In the control group,total effective rate was 78.12%;8 cases（25.00%） recovered,12 cases（37.50%） were notably effective,5 cases（15.62%） were effective,and the procedure was invalid in 7 cases（21.88%）.Curative effects were significantly different between the two patient groups（P0.05）.Before treatment,IFN-γ levels were lower and IL-4,IgE levels were higher in the patient group compared with the healthy group（P0.05）,while no differences were noted between the treatment group and the control group（P0.05）.After treatment,IFN-γ levels increased while IL-4 and IgE levels decreased notably in the treatment group in comparison with the control group with significant differences noted（P0.05）. Conclusion Back-shu point acupuncture combined with pricking and cupping therapy exhibits satisfiable efficacy in treating chronic urticaria through elevating IFN-γ level while lowering IL-4 level,correcting Th1/Th2 imbalance,lowering IgE level,and thus achieving lower transmitter release and vessel permeability.
出处
《中国全科医学》
CAS
CSCD
北大核心
2011年第28期3292-3294,共3页
Chinese General Practice
关键词
慢性荨麻疹
穴
背俞
刺络拔罐
机体免疫
Chronic urticaria
Point
back shu
Needling and cupping
Body immunization
