摘要
目的探讨外阴阴道念珠菌病(VVC)的临床特征和抗真菌药物敏感性。方法对900例VVC患者采用Soble分类对临床特征进行评分,培养、分离菌株,并对不同菌株进行酮康唑、伊曲康唑、氟康唑、两性霉素B体外药敏试验。结果单纯型VVC的临床特征平均分显著低于非白念珠菌VVC和RVVC(P<0.05);689例(76.56%)为白念珠菌,211例(23.44%)为非白念珠菌,两性霉素B的敏感性均为100%,白念珠菌对四种药物的敏感性间有显著性差异(χ2=9.57,P<0.01),非白念珠菌对四种药物的敏感性间有显著性差异(χ2=9.21,P<0.01)。结论白念珠菌是VVC的主要致病菌,念珠菌对唑类药物敏感性有所差异,非白念珠菌的药物敏感性较白念珠菌低,白念珠菌的耐药性不常见。
Objective To investigate the clinical characteristics of vulvovaginal candidiasis （ VVC ） and antifungal susceptibility of candida bacterial strain. Methods We appraised the clinical characteristics of 900 cases with VVC by Soble systematization, cultured and isolated of candida bacterial strains, checked out the antifungal susceptibility of different bacterial strains for ketoconazole, itraconazole, fluconazole and amphoterincin B. Results The clinical symptom of simple VVC was lighter than VVC of non-Candida albicans and recurrent VVC.689 cases （76,56%）were Candida albicans, 211cases （23.44%）were non-Candida albicans isolates. The susceptibility of amphoterincin B were 100%, the susceptibility of Candida albicans for 4 kinds of antifungal drug had statistical significance （ χ2=9.57, P 〈 0.01 ）, the susceptibility of non-Candida albicans isolates for 4 kinds of antifungal drug had statistical significance （χ2=9-21, P 〈 0.01 ）. Conclusion The candida albicans is the main pathogenic bacteria of VVC, the antifungal susceptibility of candida is different, the antifungal susceptibility of non-Candida albicans isolates is lower than Candida albicans, the drug resistance of Candida albicans is unfrequent.
出处
《中国现代医生》
2011年第29期45-46,79,共3页
China Modern Doctor
关键词
外阴阴道念珠菌病
临床特征
抗真菌药物
药物敏感性
Vulvovaginal candidiasis
Clinical characteristics
Antifungal drug
Susceptibility
