摘要
目的了解老年重症监护病房(ICU)铜绿假单胞菌的耐药情况,为临床合理使用抗菌剂提供依据。方法采用法国生物梅里埃公司的VPI微生物自动鉴定系统,对2008年1月至2010年10月,大于65岁老年ICU和老年普通病房患者的各类临床标本进行细菌分离、鉴定,药敏试验采用K-B纸片扩散法,并分析结果。结果老年ICU铜绿假单胞菌检出数为382株,呼吸内科ICU195株、神经内科ICU187株,其中由痰标本中所获菌株最多(84.5%)。524株铜绿假单胞菌对抗菌药物敏感率依次为多粘菌素、头孢哌酮/舒巴坦、美罗培南、亚胺培南、阿米卡星。老年ICU患者感染铜绿假单胞菌的耐药情况较普通病房严重。结论应定期监测ICU病原菌分布和耐药情况,为临床合理使用抗菌药物提供参考,达到控制医院感染,减少新的耐药菌株出现的目的。
Objective To understand the drug-resistance of Pseudomonas aeruginosa（P.aeruginosa） in elderly patients of intensive care unit（ICU） and provide proof for rational administration in clinic.Methods From Jan.2008 to Oct.2010,different types of clinical samples from patients,more than 65 years old,of ICU and other common wards were collected. Bacteria,isolated from all samples,were identified by using VPI system and drug-resistance was determined by using Kirby-Bauer method.Results Among 382 strains of P.aeruginosa,195 were isolated from samples of department of respiratory diseases ICU and 187 were isolated from samples of department of neurology ICU,and 84.5% were isolated from sputum samples. The sensitivity of 524 strains of P.aeruginosa to antibacterial drugs,ranged from high to low,were Polymyxin B,cefoperazone/sulbactam,meropenem,imipenem and amikacin. Drug-resistance of P.aeruginosa isolated from samples of ICU was severe than those from samples of common wards.Conclusion Distribution and drug-resistance of pathogen should be monitored regularly for providing reference for rational administration in clinic,controlling hospital infection and decreasing drug-resistant strains.
出处
《国际检验医学杂志》
CAS
2011年第16期1826-1827,1829,共3页
International Journal of Laboratory Medicine
基金
湖南省医药卫生科研计划项目(B2009069)
关键词
假单胞菌
铜绿
重症监护病房
抗药性
pseudomonas aeruginosa
intensive care unit
drug resistance
