摘要
骨骼肌能够根据环境刺激的变化改变其质量,可以通过细胞融合或提高蛋白质水平来增加它的大小。介绍了参与骨骼肌生长发育调控的两个关键性信号通路——胰岛素样生长因子1和肌肉生长抑制素信号通路中新的且重要的研究结果,这对于了解肌肉的发育和成年期肌肉稳态的维持,并寻找肌肉相关疾病潜在的治疗靶点非常有意义。
Skeletal muscle is a dynamic tissue adaptive to environmental stimuli such as exercise,nutrients and starvation,and either increase or decrease its mass accordingly.Two key signalling pathways mediated by either Insulin Like Growth Factor 1（IGF-1） or myostatin were identified by controling these processes through either positive or negative mechanisms respectively.The important and novel research progress on the molecules and the signalling pathways was discussed.
出处
《生物学杂志》
CAS
CSCD
2011年第5期70-72,76,共4页
Journal of Biology
基金
国家自然科学基金资助项目(30470902)
山东省自然科学基金项目(Y2007D13)
