摘要
目的:探讨阿胶对小鼠免疫功能的影响。方法:小鼠连续皮下注射氢化可的松建立免疫机能低下模型,用不同剂量的阿胶灌胃小鼠28d后,分别测定小鼠的免疫器官重量、血清溶血素水平、迟发型变态反应、脾淋巴细胞增殖、腹腔巨噬细胞吞噬能力、血清中细胞因子白介素-3(IL-3)、γ-干扰素(IFN-γ)和白介素-4(IL-4)水平。结果:阿胶能显著升高免疫低下模型小鼠胸腺指数(P<0.05,P<0.01);显著提高小鼠血清溶血素含量(P<0.01);显著促进小鼠的迟发型变态反应和脾淋巴细胞的增殖能力(P<0.05,P<0.01);显著升高小鼠腹腔巨噬细胞对鸡红细胞的吞噬率和吞噬指数(P<0.05,P<0.01);显著提高血清中细胞因子IL-3和IFN-γ水平(P<0.05,P<0.01),降低IL-4水平(P<0.05,P<0.01),提高IFN-γ/IL-4的比值(P<0.01)。结论:阿胶对小鼠特异性及非特异性免疫机能具有显著调节作用。
Objective：The effects of Colla Corii Asini on immune function in hypoimmune mice were investigated.Methods：Different dosage of Colla Corii Asini was given to hypoimmune model mice induced by Hydrocortisone.The spleen and thymus index,hemolysin content,delayed-type hypersensitivity（DTH）,spleen lymphocyte transformation,phagocytosis ability of celiac macrophage,level of interleukin-3（IL-3）,γ-interferon（IFN-γ）and interleukin-4（IL-4）were measured,respectively.Results：Colla Corii Asini could increase the thymus index（P0.05,P0.01）,hemolysin content（P0.01）,DTH level and spleen lymphocyte transformation（P0.05,P0.01）obviously.It can also promote phagocytosis ability of celiac macrophage（P0.05,P0.01）and the level of IL-3 and IFN-γ（P0.05,P0.01）,reduce the level of IL-4（P0.05,P0.01）,improve IFN-γ/IL-4（P0.01）obviously.Conclusion：Colla Corii Asini can stimulate both specific and non-specific immune function in mice.
出处
《食品工业科技》
CAS
CSCD
北大核心
2011年第11期400-402,433,共4页
Science and Technology of Food Industry
基金
国家高技术研究发展计划项目(2007AA091805)
国家自然科学基金项目(30972284和30871944)
