摘要
胃癌是常见消化系统恶性肿瘤,居全球恶性肿瘤死亡率的第2位。胃镜活检组织病理学检查是早期诊断胃癌最有效的手段,但因费用高、人群接受度较低而难以作为普查手段。血液肿瘤标记物检测具有操作简便、无创、便于动态监测等优点,因此易为受试者所接受。寻找高特异性和敏感性的胃癌血液肿瘤标记物,对实现高危预警、早期诊治、改善胃癌预后具有重要意义。本文就血液肿瘤标记物胃癌相关抗原MG7-Ag、M2-丙酮酸激酶(PK)、上皮细胞黏附分子(Ep-CAM)、CA72-4以及常用肿瘤标记物联合检测在胃癌早期诊断中的相关研究进展作一综述。
Gastric cancer is a common gastrointestinal malignancy, and is the second leading cause of cancer deaths worldwide. The most effective method for early diagnosis of gastric cancer is endoscopic biopsy with histopathology. Given the high cost and low acceptance, it can not be used for large scale screening. Deteclion of blood tumor markers is relatively simple, non-invasive, easy for dynamic monitoring, and is quite acceptable. Therefore, in order to achieve high risk warning, early diagnosis and treatment thus to improve the outcome of patients with gastric cancer, it is of great importance to find blood tumor markers of gastric cancer with high specificity and sensitivity to be used for screening. This article reviewed the advances in studies on blood tumor markers, such as gastric cancer-associated MG7-Ag, M2-pyruvate kinase （M2-PK）, epithelial cell adhesion molecule （Ep-CAM）, CA72-4 and the combination of routine tumor markers for early diagnosis of gastric cancer.
出处
《胃肠病学》
2011年第9期569-571,共3页
Chinese Journal of Gastroenterology
基金
上海市科学技术委员会科研计划项目资助(No.10JC1419000)
关键词
胃肿瘤
诊断
肿瘤标记
生物学
Stomach Neoplasms
Diagnosis
Tumor Markers, Biological
