摘要
目的:探讨核转录因子Spl在肾透明细胞癌(renal clear cell carcinoma,RCCC)组织中的表达特征和临床意义。方法:用免疫组织化学PV-6000法,检测59例RCCC和11例正常肾脏组织中Spl的表达,分析其与肿瘤分级和分期的关系。结果:Spl在RCCC组织中阳性表达率为71.2%(42/59),明显高于正常肾组织的18.2%(2/11)。Sp1蛋白阳性表达与RCCC的组织学分级和临床分期正相关。结论:转录因子Spl可作为一个新的与RCCC发生、发展密切相关的生物学标记物。
Objective：To investigate the expression of transcription factor Spl in renal clear cell carcinoma（RCCC） and its clinical significance.Methods： By using immunohistochemical PV-6000 method to study the expressed level of Spl in 59 cases of RCCC and 11 cases of normal renal specimen.Results： The positive expression rate of Spl protein（71.2%） in RCCC was significantly higher than that in normal renal tissue（18.2%）,and the positive expressed level of Spl was closely related to pathological grading and TNM stages of RCCC.Conclusion： Spl may act as a new biological marker that closely related to the carcinogenesis and progression of RCCC.
出处
《现代肿瘤医学》
CAS
2011年第10期2040-2041,共2页
Journal of Modern Oncology
基金
河南省开封市科技局专项资金支持(编号:100338)
关键词
转录因子Spl
肾癌
阳性表达
免疫组化
Spl
renal cell carcinoma
positive expression
immunohistochemistry
