摘要
目的:探讨布地奈德联合特布他林雾化液雾化吸入治疗小儿毛细支气管炎的临床疗效。方法:选择该院2007年3月～2010年3月收治的72例住院毛细支气管炎患儿作为观察对象,根据治疗方法的不同随机分为治疗组和对照组各36例,两组均常规给予抗感染、化痰、静滴地塞米松0.2 mg.kg-1.d-1,每天1次,双肺喘鸣音消失后改为口服强的松0.75 mg.kg-1.d-1,每天3次,同时予吸氧、镇静、补液、营养支持等治疗,治疗组在常规治疗基础上给予生理盐水1 ml/次+布地奈德雾化液0.5 mg/次+特布他林雾化液2.5 mg/次(阿斯利康有限公司生产)氧气驱动雾化吸入,氧流量为6～8 L/min,5～10 min/次,每天2次,雾化至临床症状、体征消失。比较两组的疗效及临床症状体征改善情况。结果:治疗组有效率为94.44%,对照组有效率为83.33%,两组患者疗效及有效率比较差异有统计学意义(P<0.05)。全部患者未见明显的不良反应。治疗组咳嗽、喘憋、喘鸣音及肺部啰音的消失时间明显短于对照组,且住院时间也短于对照组(P<0.05)。结论:布地奈德、特布他林溶液联合雾化吸入治疗小儿毛细支气管炎疗效确切,可以明显改善患者的临床症状,缩短住院时间,安全无痛苦,小孩易接受,值得临床推广。
Objective ： To explore the clinical curative effect of aerosol inhalation of budesonide combined with terbutaline in treat- ment of infantile bronchiolitis. Methods ： 72 hospitalized infants with bronchiolitis who were treated in the hospital from March 2007 to March 2010 were selected as observation objects, then they were divided into treatment group and control group according to different therapies, 36 infants in each group ; the infants in the two groups were treated with anti - infection, resolving phlegm and intravenous drip of dexamethasone （0. 2 mg ·kg^-l · d^-1, once a day）, oral administration of prednisone after disappearance of bilateral pulmonary wheezing tales （0. 75 mg · kg^- 1 · d^- l, three times a day ） , oxygen inhalation, sedation, fluid infusion and nutritional support; the infants in treatment group were treated with oxygen drive atomization inhalation of normal saline （ 1 ml per time） ＋ budesonide atomized liquid （ 0. 5 mg per time） ＋ terbutaline atomized liquid （2. 5 mg per time）, the oxygen flow was 6- 8 L per minute, 5- 10 minutes per time, twice a day, the treatment continued until the disappearance of clinical symptoms and signs. The curative effects and improvements of clinical symptoms and signs in the two groups were compared. Results： The effective rates in treatment group and control group were 94.44% and 83. 33%, re- spectively, there was significant difference in the curative effect and effective rate between the two groups （ P 〈 0.05 ） . No apparent adverse reactions occurred in the two groups. The disappearance times of cough, wheezing, wheezing rales and pulmonary rales and the hospitaliza- tion time in treatment group were significantly shorter than those in control group （ P 〈 0. 05 ） . Conclusion ： The curative effect of aerosol inhalation of budesonide combined with terbutaline is good in treatment of infantile bronehiolitis, the therapy can improve the clinical symp- toms and shorten the hospitalization time, which has the advantages of safety, painlessness and easy to be accepted by infants, it is worthy to be popularized in clinic.
出处
《中国妇幼保健》
CAS
北大核心
2011年第29期4609-4610,共2页
Maternal and Child Health Care of China
