摘要
目的:观察奇正消痛贴膏对早中期膝关节骨性关节炎关节液中一氧化氮(NO)和基质金属蛋白酶-13(MMP-13)含量的影响及临床疗效,并与扶他林乳胶剂组做对照。方法:将60例患者分成治疗组和对照组,奇正消痛贴膏为治疗组,扶他林乳胶剂作对照组,治疗1周及2周后,分别观察患者的美国特种外科医院膝关节评分(HSS)总分、疼痛积分,并进行计分对比分析,同时测定治疗组治疗前后关节液中NO和MMP-13含量,评价其临床疗效,进行疗效观察。结果:通过统计学分析,治疗组治疗1周及治疗2周后与治疗前进行HSS量表中HSS总分、疼痛积分比较,P<0.05;治疗组按疗程治疗前后关节液中NO含量经配对t检验,P<0.05。结论:奇正消痛贴膏对早中期膝关节骨性关节炎有较好的治疗作用。
Objective： To observe the impact and clinical effect of the Qizheng xiaotong plaster to the levels of MMP-13 and NO in synovial fluid on patients with knee osteoarthritis in early and mid-term, and compare with the Voltaren emulsion group. Methods： 60 patients were divided into two groups： the treatment group with the Qizheng xiaotong plaster and the control group with the Voltaren emulsion. After one or two weeks, the HSS score and the pain score were observed respectively, and then contrasted and analyzed the results. Meanwhile, identified the content of NO and MMP-13 on treatment group and observed the effect and analyzed the clinical effect. Results： Through the statistical analysis, compared the HSS score and the pain score on treatment group in one or two weeks later, P0.05; The treatment group was identified synovial fluid of NO content by paired t test before and after treatment, P0.05. Conclusion： Qizheng xiaotong plaster is effective in treating early and mid-knee osteoarthritis.
出处
《中国当代医药》
2011年第30期97-98,共2页
China Modern Medicine
