摘要
背景:关节软骨修复再生能力较差,软骨缺损的修复与功能重建是关节外科的一大难题,也是近年研究热点之一,而软骨组织工程技术的发展为其提供了新的思路和方法。目的:总结和分析脐血间充质干细胞的生物学特性及其在软骨组织工程中的研究与应用。方法:通过计算机检索中国期刊全文数据库及PubMed数据库2000-01/2010-12的有关文献资料,分别以"脐血间充质干细胞,组织工程,软骨缺损"为中文检索词,"umbilical cord blood mesenchymal stem cells,tissue engineering,cartilage repair"为英文检索词,纳入脐血间充质干细胞和软骨组织工程的相关文献,排除重复性研究,共选取33篇文献做进一步分析。结果与结论:脐血间充质干细胞以其固有的取材方便、免疫原性较弱、分化能力强以及被病毒细菌污染率低等特有的优势,成为软骨组织工程理想的种子细胞,将在未来软骨组织工程的研究及应用中发挥重要的作用。
BACKGROUND：Due to the poor repair capacity of articular cartilage,it is still a difficult problem to repair and reconstruct articular cartilage defects in orthopedics,and it is also one of the research foci in recent years.But,the development of cartilage tissue engineering provides a new way for repairing articular cartilage defects.OBJECTIVE：To conclude and analyze the biological characteristics of umbilical cord blood mesenchymal stem cells and their research and application in cartilage tissue engineering.METHODS：We searched CNKI and PubMed database for literatures from January 2000 to December 2010.Key words were ＂umbilical cord blood mesenchymal stem cells,tissue engineering,cartilage repair＂.Articles on Umbilical cord blood mesenchymal stem cells and cartilage tissue engineering were included,and repetitive studies were excluded.Finally,33 articles were selected for further analysis.RESULTS AND CONCLUSION：Umbilical cord blood mesenchymal stem cells,as ideal seed cells of cartilage tissue engineering,are easy to obtain,and have weak immunogenicity,strong differentiation,low rate of bacterial contamination by viruses and other unique advantages.And it is will play an important role in cartilage tissue engineering.
出处
《中国组织工程研究与临床康复》
CAS
CSCD
北大核心
2011年第36期6809-6812,共4页
Journal of Clinical Rehabilitative Tissue Engineering Research
基金
海南省自然科学基金项目(309107)
2010海口市重点科技计划项目(2010-168)~~
