摘要
目的通过回顾性分析总结＂三阴＂型乳腺癌与非＂三阴＂型乳腺癌患者的流行病学及生物学行为特点,以便为指导临床个体化治疗、判定预后奠定基础。方法收集并整理宁夏医科大学附属医院及银川市人民医院2002年1月~2004年12月收治、经病理组织学确诊,且有5年完整随访数据的乳腺癌患者231例。采用SPSS11.5统计学软件对＂三阴＂型与＂非三阴＂型乳腺癌患者的流行病学、临床病理学特点、复发转移、5年生存等方面进行分析。结果＂三阴＂型乳腺癌占17.3%,与非＂三阴＂型乳腺癌患者相比,原发肿瘤大（P〈0.05）,复发转移率尤其是内脏转移率高,3年、5年生存率明显降低,其中所占比例居多的Ⅱ期及淋巴结阳性患者5年生存率也较对照组明显降低（P〈0.05）。Cox比例风险模型进行预后因素分析,本组患者发病年龄、原发肿块大小、临床分期及是否为＂三阴＂性表达均为乳腺癌的独立危险因素。结论＂三阴＂型乳腺癌与非＂三阴＂型乳腺癌相比,局部侵袭性强、复发转移率及内脏转移率高、预后差、生存率低＂。三阴＂型乳腺癌为影响乳腺癌患者预后的独立危险因素。
Objective To summarize the epidemiological and biological features of triple-negative breast cancer（TNBC） and non-triple-negative breast cancer（non-TNBC） to provide reference for devising individualized therapy and making prognostic evaluation.Methods The 5-year follow-up data were collected from 231 patients with pathologically established diagnosis of breast cancer treated in the Affiliated Hospital of Ningxia Medical University and Yinchuan People＇s Hospital between Jan.2002 and Dec.2004.The epidemiological and clinicopathological characteristics as well as the recurrence,metastasis and 5-year survival were compared between TNBC group and non-TNBC group.Results TNBC accounted 17.3% of the total breast cancer cases enrolled in this study.The tumor size and rates of recurrence and metastasis（especially visceral metastasis） were significantly greater in TNBC group than in non-TNBC group（P0.05）.The TNBC patients showed significantly lower 3-and 5-year survival rates than the non-TNBC patients（P0.05）,and TNBC patients with positive lymph nodes in clinical stage II had also a lower 5-year survival（P0.05）.Cox regression model analysis identified the patients＇ age,primary tumor size,clinical stages and triple-negativity as the independent risk factors for breast cancer.Conclusions Compared to non-TNBC patients,patients with TNBC have higher rates of local recurrence and invasion,visceral metastasis and poorer prognosis,and a lower rate of 5-year survival.The triple negativity represents an independent factor for prognosis evaluation of breast cancer.
出处
《南方医科大学学报》
CAS
CSCD
北大核心
2011年第10期1729-1732,共4页
Journal of Southern Medical University
基金
教育部春晖计划项目(z2008-1-75006)
关键词
乳腺癌
雌激素受体
孕激素受体
人类表皮生长因子受体-2
breast cancer
estrogen receptor
progesterone receptor
human epidermal growth factor receptor-2
