摘要
目的:了解南京地区性病门诊患者支原体感染现状及药物敏感状况,为临床医生科学诊断和治疗支原体感染型非淋菌性尿道炎/宫颈炎(简称NGU)提供参考依据。方法:对2008年1月至2010年12月南京性病门诊1 178例疑似NGU的就诊患者,收集生殖道分泌物,进行解脲脲原体(Uu)和人型支原体(Mh)培养、鉴别、计数、药敏试验。结果:1 178例患者中检出解脲脲原体535例(检出率为45.4%),人型支原体27例(检出率为2.3%),Uu+Mh 185例(检出率为15.7%);解脲脲原体阳性率以20岁组和30岁组性活跃人群为主,约占总检出率的71.8%,男女比例约为1∶1.8,差异有统计学意义(χ2=112.7,P<0.01)。解脲脲原体和人型支原体同时阳性也以20岁组和30岁组为主,约占总检出率的70.3%,男女比例接近1∶3.7,差异有统计学意义(χ2=87.6,P<0.01)。药物敏感性试验结果显示,支原体敏感性较好的药物是美满霉素(MIN)、强力霉素(DOX)和交沙霉素(JOS),耐药率较高的是氧氟沙星(OFL)和罗红霉素(ROX)。结论:NGU患者泌尿生殖道具有较高的Uu感染率;大多数支原体对美满霉素和强力霉素敏感,这两种药可作为治疗性病门诊支原体感染型患者的首选药物。
Objective： To facilitate scientific diagnosis and normative treatment non-gonococcal urethritis/cervicitis（referred to as NGU）.Methods： Genitourinary tract secretion of 1 178 cases who were suspected patients with NGU of STD outpatients in Nanjing from January 2008 to December 2010 was used to cultivate,followed by identification and count of mycoplasma and the detection of antibiotic susceptibility of these strains.Results： Mycoplasm culturing result showed that among the 1 178 cases,the positive rates of Uu,Mh and ＂Uu and Mh＂ were 45.4%,2.3%,15.2%,respectively.For Uu infection status,the significant difference was found between female（64.3%） and male（35.7%）.The positive rates had significant differences among different age groups,20 years and 30 years group were higher.For ＂Uu＋Mh＂ infection status,the significant different was found between female（78.9%） and male（21.1%）.The positive rates had significant differences among different age groups,20 years and 30 years group were higher.Drug sensitivity test result showed that the highest sensitivity of mycoplasma to eight kinds of antibiotics was minocycline（MIN）,secondly was doxycycline（DOX）,thirdly was josamycine（JOS）.The highest resistance of mycoplasma was ofloxacin（OFL）,secondly was roxithromycin（ROX）.Conclusions： NGU patients with genitourinary tract infection have a higher Uu infection rate.Most of the mycoplasma are sensitive to minocycline（MIN）,doxycycline（DOX）.This two kinds of drugs are the first choice for the treatment of mycoplasma infection in STD clinic patients.
出处
《东南大学学报（医学版）》
CAS
2011年第5期758-761,共4页
Journal of Southeast University(Medical Science Edition)
关键词
泌尿生殖道
解脲脲原体
人型支原体
药物敏感性试验
urogenital tract
ureaplasma urealyticum
mycoplasma hominis
drug sensitivity test
