期刊文献+

胃癌辅助化疗的选择和应用 被引量:8

Adjuvant Chemotherapy for Gastric Cancer: Choice and Use
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摘要 局部进展期胃癌手术后是否给予全身辅助化疗以及关于标准方案的临床研究,一直是临床关注的热点问题,对ⅡB期以上的进展期胃癌术后给予辅助治疗已经成为共识,但对于采用何种方案作为标准方案尚缺乏循证学依据,而且东西方医学界的意见存在较大的争议,我们一方面期待具有更高级别证据的临床研究结果,另一方面在现有证据下对胃癌术后进行最大程度规范化的辅助治疗,以提高我国胃癌整体治疗的水平。 It is a hot point that postoperative chemotherapy is used on local advanced gastric cancer(LAGC). There is a consensus that adjuvant therapy after surgery is necessary to LAGC of stage ⅡB and above. But an obvious controversy between eastern and western oncologists is difference on standard therapy due to deficiency of clinical study with evidence based medicine (EBM). We must be making standard adjuvant therapy as much as possibly on LAGC with these outcomes and looking forward to new clinical study with high EBM level.
作者 张弦 张阳
出处 《医学与哲学(B)》 2011年第10期18-19,43,共3页 Medicine & Philosophy(B)
关键词 局部进展期胃癌 辅助化疗 临床研究 local advanced gastric cancer, adjuvant chemotherapy/therapy, clinical study
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  • 1Hermans J, Bonenkamp J J, Boon M C, et al. Adjuvant therapy after curative resection for gastric cancer~ meta-- analysis of ran- domized trials[J]. J Clin Oncol, 1993,11(8) : 1441 - 1447.
  • 2Earle C C, Maroun J A. Adjuvant chemotherapy after curative re- section for gastric cancer in non--Asian patients~ revisiting a meta --analysis of randomised trials[J]. Eur J Cancer, 1999, 35 (7): 1059-1064.
  • 3Mari E, Floriani I, Tinazzi A, et al. Efficacy of adjuvant chemo- therapy after curative resection for gastric cancer: a meta--analysis of published randomised trials. A study of the GISCAD[J]. Ann Oncol,2000,11(7) :837-843.
  • 4Janunger K G, Hafstr6m L, Glimelius B. Chemotherapy in gastric cancer : a review and updated meta- analysis[J]. Eur J Surg,2002, 168(11) :597-608.
  • 5Zhao S L, Fang J Y. The role of postoperative adjuvant chemother- apy following curative resection for gastric cancer : a meta- analysis [J]. Cancer Invest, 2008, 26(3) :317-325.
  • 6Liu T S, Wang Y, Chen S Y, et al. An updated meta-analysis of adjuvant chemotherapy after curative resection for gastric cancer[J]. EurJ SurgOncol,2008, 34(11) :1208-1216.
  • 7Sun P, Xiang J B, Chen Z Y. Meta-analysis of adjuvant chemo- therapy after radical surgery for advanced gastric cancer[J]. Br J Surg,2009,96(1):26-33.
  • 8GASTRIC (Global Advanced/Adjuvant Stomach Tumor Research International Collaboration) Group. Benefit of adjuvant chemother- apy for resectable gastric cancer: a meta- analysis[J]. JAMA,2010, 303(17):1729-1737.
  • 9Sakuramoto S, Sasako M, Yamaguchi T, et al. Adjuvant chemo- therapy for gastric cancer with S-1, an oral fluoropyrimidine[J]. N Engl J Med,2007,357(18) ,1810-1820.
  • 10Adjuvant capecitabine and oxaliplatin for gastric cancer: Results of the phase Ⅲ CLASSIC trial[G]. 2011 ASCO Annual Meeting Ab- stract No : LBA4002.

同被引文献86

  • 1俞倩,陈中安.局部进展期胃癌根治术后采取同期放化疗的临床效果分析[J].实用癌症杂志,2014,29(3):281-283. 被引量:6
  • 2岳顺,张大红,周磊磊.雷替曲塞联合多西他赛治疗晚期胃癌的临床疗效[J].肿瘤防治研究,2014,41(2):160-162. 被引量:21
  • 3杨鹏飞.进展期胃癌术后辅助化疗加参芪扶正液的疗效观察[J].包头医学院学报,2005,21(2):133-134. 被引量:3
  • 4李铁汉,黄洁,马俊峰,张捷,田大广,李文,阿永俊,魏晓平,胡明道.FOLFOX4方案用于进展期胃癌术后辅助化疗的临床观察[J].临床外科杂志,2007,15(10):690-691. 被引量:6
  • 5Roth AD,Fazio N,Stupp R,et al.Docetalxel,cisplatin,and fluorouracil;docetaxel and cisplatin;and epirubicin,cisplatin,and fluorouracil as systemic treatment for ad-vanced gastric carcinoma:A randomized phase II trial of the Swiss Group for Clinical Cancer Research [ J ].J Clin 0n-col,2007,25(22):3217-3223.
  • 6Koizumi W,Narahara H,Hara T,et al.S-1 plus cispla-tin versus S-1 alone for first-line treatment of advanced gastric cancer(SPIRITS trial):a phase Ⅲ trial [J].Lan-cet Onco1,2008,9(3):215-221.
  • 7Kang YK,Kang WK,Shin DB,et al.Capecitabine/cispl-atin versus 5-Fluorouracil/cisplatin as first-line therapy in patients with advanced gastric cancer:a randomiazed phase Ⅲ noninferiority trial [ J ].Ann 0ncol,2009,20(4):666-673.
  • 8Salah-Eldin MA,Ebrahim MA,AL-Ashry MS.Phase Ⅱ study of capecitabine plus cisplatin in patients with gas-tric cancer [ J ].Anticancer Drugs,2009,20(3):191-196.
  • 9Cunningham D,Starling N,Rao S,et al.Capecitabine and oxaliplatin for advanced esophagogastric cancer[ J].N Engl J Med,2008,358(1):36-46.
  • 10Park YH,Kim BS,Ryoo BY,et al.A phase Ⅱ study of capecitabine plus 3-weekly oxaliplatin as first-line thera-py for patients with advanced gastric cancer[ J].Br J Canc-er,2006,94(7):959-965.

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