摘要
目的:探讨葛根素对糖尿病大鼠肾脏的保护作用。方法:(1)采用链脲佐菌素制备糖尿病大鼠模型,给药24周后计算大鼠肾指数,检测血肌酐、血尿素氮含量,每4周检测葛根素对糖尿病大鼠空腹血糖的影响。(2)制作肾脏组织切片,观察肾脏病理变化,分析肾小球相对平均体积(CVG)及肾小管-间质损伤指数(TII)。结果:(1)葛根素可明显降低糖尿病大鼠血糖,血肌酐和血尿素氮的含量(P<0.05,P<0.01);(2)葛根素可改善糖尿病大鼠肾脏病理损伤,降低CVG(P<0.01)、减轻TII(P<0.01)。结论:葛根素对糖尿病大鼠肾脏具有保护作用。
Objective： To assess the protection of puerarin for the kidney of diabetic rats.Methods：（1）Rats were induced by streptozotocin（STZ） as diabetic ones.After administering 24weeks,the kidney index（KI） was calculated,and serum creatinine（Scr） and blood urea nitrogen（BUN） were detected.Every 4weeks the fasting blood glucose（FBG） was detected to investigate the effect of puerarin on the diabetic rats.（2）After making nephridial tissue microtome section,the Correspondence Glomerular volume（CVG） and indices for tubulointerstitial injury（TII） via were analyzed by using computer image analysis software.Meanwhile the microscope was used to observe the changes of nephridial tissue.Results：（1）Puerarin can decrease the content of Scr,BUN and FBG（P〈0.05,P〈0.01）;（2） Puerarin can improve the nephridial tissue impairment of the diabetic rats,decrease CVG（P〈0.01） and lessen TII（P〈0.001） significantly.Conclusion： Puerarin has the Protection for the Kidney of Diabetic Rats.
出处
《交通医学》
2011年第4期333-336,共4页
Medical Journal of Communications
基金
香港保健协会研究项目(NO.20050908-2
HK)
