摘要
目的:探讨利培酮和舒必利对首发精神分裂症患者血脂代谢的影响。方法:2006年2月至2009年2月期间我院门诊或住院的精神分裂症患者213例,测定利培酮或舒必利治疗8周前后的血胆固醇及三酰甘油浓度。结果:利培酮治疗后,血胆固醇(TC)及血三酰甘油(TG)明显升高(t=2.316,P<0.05;t=2.438,P<0.05),且男性患者组升高较三酰甘油明显(t=2.118,P<0.05;t=2.132,P<0.05);舒必利组治疗后血三酰甘油明显升高(t=2.355,P<0.05),且女性TG升高的程度显著大于男性患者(t=2.68,P<0.01)。结论:利培酮治疗后血胆固醇及三酰甘油水平升高,男性更明显。舒必利治疗后血三酰甘油水平升高,女性更明显。利培酮对TC的影响大于舒必利。
Objective：To explore the side-effects of risperidone on the lipid metabolism in schizophrenic patients with their first episode.Method：213 first-episode schizophrenic outpatients or inpatients were recruited from January 2006 to January 2009.To exam the concentrations of total cholesterol（TC） and triglyceride（TG） after 8 week risperidone or sulpiride treatment.Results：After risperidone treatment,TC and TG concentrations were significantly increased（t=2.316,P〈0.05;t=2.438,P〈0.05）.Moreover,male patients had the more severe side-effects on the lipid metabolism than female（t=2.118,P〈0.05;t=2.132,P〈0.05）.After sulpiride treatment,TG concentrations were significantly increased（t=2.355,P〈0.05）.Moreover,TG concentrations of female patients increased more than those of male（t=2.68,P〈0.01）.Conclusion：Risperidone raises the TC and TG concentrations,and more greatly in male patients.Sulpiride raises the TG concentrations,and more greatly in female patients.Risperidone has more effects on TC than sulpiride.
出处
《临床精神医学杂志》
2011年第5期329-330,共2页
Journal of Clinical Psychiatry
基金
上海市卫生局科研基金(2009Y051)
关键词
利培酮
舒必利
首发
精神分裂症
血脂
risperidone
sulpiride
first-episode
schizophrenia
blood lipid
