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新型芳香吲唑酮类化合物的合成与表征

Synthesis and Characterization of Novel Aromatic Indazolone Derivatives
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摘要 以p-取代苯胺为原料,经重氮化反应后再与2-氯乙酰乙酸乙酯反应制得(Z)-4-[2-(1-氯-2-乙氧基-2-羰亚甲基)肼基]-取代苯(2a～2i);在无水乙醇中,2a～2i分别与5,5-二甲基-1,3-环己二酮发生环化反应合成了9个新型的芳香吲唑类化合物(3a～3i),其结构经1H NMR和MS表征。 （Z）-4-[2-（1-chloro-2-ethoxy-2-oxoethylidene）hydrazinyl]substituented-benzene（2a～2i） were prepared from p-substituented-aniline by diazotization,then reacted with ethyl 2-chloro-acetoacetate.Nine novel indazolone derivatives（3a～3i） were synthesized by cyclization of 2a～2i with 5,5-dimethyl-cyclohexane-1,3-dione,respectively.The structures were characterized by 1H NMR and MS.
作者 张晓颖 张杰 于海涛 王小龙
机构地区 南京中医药大学药学院
出处 《合成化学》 CAS CSCD 北大核心 2011年第6期740-743,共4页 Chinese Journal of Synthetic Chemistry
关键词 HSP90抑制剂 苯胺 环己二酮 芳香吲唑酮类 合成 Hsp90 inhibitor aniline cyclohexane-1 3-dione aromatic indazolone synthesis
分类号 O626.2 [理学—有机化学] R914.5 [医药卫生—药物化学]
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参考文献7

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二级参考文献23

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共引文献5

合成化学
2011年 第6期

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