摘要
目的探讨外周血清脑源性神经营养因子(brain derived neurotrophic factor,BDNF)浓度与精神分裂症伴发的迟发性运动障碍(tadrive dyskinesia,TD)的关系。方法收集精神分裂症伴发TD患者61例、不伴发TD的患者78例,以及正常对照102名。用酶联免疫吸附法检测BDNF水平,采用不自主运动量表(abnormalinvoluntary movement scale,AIMS)评估TD的严重程度,阳性和阴性症状量表(positive and negative symptomscale,PANSS)评估患者精神症状。结果 TD组、非TD组和对照组的BDNF水平分别为(9.35±1.60)μg/L、(10.12±2.03)μg/L、(12.27±2.7)μg/L,3组的差异有统计学意义(F=37.8,P<0.01);两两比较显示,TD组和非TD组均低于对照组(P<0.01),而TD组又低于非TD组(P<0.05)。使用典型和非典型抗精神病药物患者之间的BDNF水平差异无统计学意义(P>0.05)。TD组BDNF水平与AIMS总分、年龄、总病程负相关(r分别为-0.24、-0.32、-0.22,P均小于0.05),而在非TD组BDNF水平与上述因素均无相关(P>0.05)。结论精神分裂症伴发TD患者外周BDNF浓度下降,且其水平与异常运动严重程度相关,提示BDNF可能在TD的病理生理中发挥作用。
Objective To explore relationship between serum levels of brain-derived neurotrophic factors （BD- NF） and tardive dyskinesia （TD） in schizophrenic patients with TD and those without TD. Methods All patients satisfied DSM-IV criteria for schizophrenia. The serum BDNF levels were examined by using enzyme linked immunosorbent assay in patients with TD （n = 61） and patients without TD （n = 78） and controls （n = 102）. The severity of TD and psychopathology were assessed using the abnormal involuntary movement scale （AIMS） and positive and negative symp- tom scale （PANSS）, respectively. Results The patients with TD [（9.35 ± 1.60）μg/LJ and those without TD [（10.12 ± 2.03）μg/L] had lower serum BDNF levels than normal controls [（12.27 ± 2.7）μg/Ll （F = 37.8,P 〈 0.01）. The patients with TD had markedly lower serum BDNF levels than those without TD （P = 0.04）. The serum BDNF levels of patients with TD was inversely correlated with AIMS total score, age and duration of illness. In all patients, no significantly differences in serum BDNF levels was noted between atypical and typical antipsychotic treatment [（9.78 ± 1.93）μg/L vs （10.10 ±2.20） μg/L, t = -0.88, P 〉 0.05]. Conclusion The BDNF levels of schizophrenia with TD was decreased significantly. There may be a relationship between decreased BDNF levels and dyskinetic movements. BDNF may play an important role in the pathophysiology of TD.
出处
《中国神经精神疾病杂志》
CAS
CSCD
北大核心
2011年第10期614-617,共4页
Chinese Journal of Nervous and Mental Diseases
