摘要
目的:探讨卵冠丘复合体中的血凝块对IVF-ET的影响。方法:采用IVF-ET常规长方案超促排卵、获得的卵冠丘复合体上有血凝块的患者为研究对象,将其随机分为A组,切除血凝块,50例;B组,不切除,53例;另以获得的卵丘复合体上无血凝块者为对照组(C组,91例);比较分析各组的临床结局。结果:3组患者的年龄、不孕年限、Gn用量、Gn使用总天数及获卵数组间两两比较,均无统计学差异,A组的受精率及2PN率最高,为85.4%和71.1%,C组次之,为77.5%和64.9%,B组最低,为75.8%和62.2%,A组显著高于B、C组(P<0.01),B、C组间统计学差异;移植后A组的种植率、妊娠率略高于B、C组,但无统计学差异(P>0.05)。结论:切除卵冠丘复合体上的血块不会增加操作成本及操作的复杂性,但却可以近一步改善患者的助孕结局,值得推广使用。
Objective： To study the impact of blood clot in the oocyte-corona-cumulus complexes（OCCC） on IVF-ET.Methods： The OCCCs were harvested from the patients undergoing long protocol ovarian hyperstimulation.The OCCCs with blood clots removed or not,were randomly grouped to A or B.The OCCCs with no blood clot were grouped to C（as the control）.Results： The patients’ age,infertility duration,the average gonadotropin consumption,the average days of superovulation and an average number of harvested oocytes showed no significant difference among the 3 groups.The fertilization rate and 2PN rate of group A were the highest,which were 85.4% and 71.1%,respectively,followed by group C,which were 77.5% and 64.9%,respectively.The lowest were in group B,which were 75.8% and 62.2%,respectively.Those in group A were significantly higher than those in groups B and C,P〈0.01.There was no significant difference between groups B and C.Implantation rate and pregnancy rate showed no significant difference among the 3 groups after transplantation,even if group A got the highest rate among the 3 groups.Conclusion： Removing the blood clots in OCCC can improve outcome of IVF-ET without increasing the cost and complexity of the operation.
出处
《生殖与避孕》
CAS
CSCD
北大核心
2011年第10期676-679,共4页
Reproduction and Contraception
基金
广东省科技厅基金资助项目
项目编号:20101303600299
