摘要
目的探讨丙泊酚注射液不良反应发生的特点,为临床安全用药提供参考。方法以丙泊酚、不良反应、过敏等为检索词,检索中国医院知识仓库(CHKD价与)和万方数据库收载的1994～2010年所有中文文献。阅读、筛选所有描述丙泊酚不良反应的文献资料,并按患者性别、年龄、原患疾病与过敏史、累及器官或系统与临床表现、评转归等方面进行统计、分析。结果共检索到与丙泊酚注射液不良反应有关的有效文献32篇,收集不良反应37例。所有不良反应中,女性患者是男性患者的2.4倍,15～44岁年龄段人群占70.27%;不良反应损害主要表现为心血管系统损害和呼吸系统损害,构成比分别为26.88%、26.34%;16例表现为过敏性休克,1例死亡病例。23例(62.16%)不良反应发生在静脉用药后30min内,不良反应出现最快者约在用药后5秒钟。结论丙泊酚注射液不良反应临床表现复杂多样,发生过敏性休克的比率较高,严重可导致死亡。临床在使用丙泊酚注射液过程中应加强监护,保证患者用药安全。
Objective To find out the clinical features of adverse drug reactions（ADRs） induced by propofol injection and provide reference for its clinically safe application. Medhods The Chinese electronic databases of the Chinese National Knowledge Infrastructure and Wangfang data during 1994-2010 were searched with composite terms of propofol and adverse drug reaction or allergy, etc. All literatures associated with adverse drug reaction ofpropofol injection were reviewed and screened. Propofol injection-induced ADR cases were analyzed statistically in respects of demographic distribution, types of disease and allergic history, organs and systems involved in ADR, clinical manifestations and ADR outcomes, etc. Results Thirty-two of Available literatures were retrieved and total 37 adverse drug reaction cases were collected. Of all screened cases, the incidence in female patients was 2.4 times higher than that in male patients, 70.27% of those was occurred in the population of ages15-44. The lesions of adverse drug reaction involved primarily in circulation system and respiratory system, the corresponding constitutive ratio were 26.88% and 26.34%, respectively. The allergic shock happened to 16 patients（43.24%） with one death. 23（62.16%） of adverse drug reactions occurred within 30 min and the fastest adverse drug reaction case occurred about 5 seconds after injection.Corlclusion The clinical manifestations of propofol induced-ADRs are complicated and diversified. The frequency of allergic shock induced by propofol injection is high and severe cases can lead to death. Clinical physicians should pay more attention to the patient and ensure patient safety after propofol injection is administered.
出处
《中国药物警戒》
2011年第11期681-685,共5页
Chinese Journal of Pharmacovigilance
关键词
丙泊酚注射液
不良反应
文献分析
propofol injection
drug adverse reaction（ADR）
analysis
