摘要
目的:用18F-FDG PET/CT精确揭示鼻型结外NK/T细胞淋巴瘤患者的病灶,探讨病变范围与相关临床指标的关系。方法:22例初诊鼻型结外NK/T细胞淋巴瘤患者治疗前行18F-FDG PET/CT检查,分析鼻、咽部及全身病灶累及范围及播散规律,并分析不同病变范围患者之间ALB、LDH、β2-MG、SUVmax、B症状发生率之间的差异。结果:18F-FDG PET/CT发现每位患者至少有一处病灶,原发病灶在鼻腔、鼻咽、口咽部者分别占81.9%、9.1%、9.1%。病变累及最多的部位为鼻腔(95.5%,21/22)、鼻咽(54.5%,12/22)、左颈部淋巴结(40.9%,9/22)、右颈部淋巴结(40.9%,9/22)、口咽(36.4%,8/22)等。鼻、咽部原发病灶可向邻近部位播散,也可沿淋巴结群依次播散,还可以跳跃方式向远处器官播散。病灶范围较广者组,SUVmax值显著增加,血清β2-MG升高者比例也显著增加。结论:18F-FDG PET/CT能精确发现鼻型结外NK/T细胞淋巴瘤患者鼻、咽部及全身病灶,血清β2-MG水平也能反映病灶的累及范围。
Objective：To detect the lesions using 18F-FDG PET/CT in patients with extranodal nature killer/T-cell lymphoma,nasal type and investigate the relationship between disease range and related clinical parameters.Method：Twenty-two diagnosed patients with extranodal NK/T-cell lymphoma in nasal type who received ^18F-FDG PET/CT were studied.The lesion with intense F-FDG uptake was defined as the positive and the primary lesion was measured using maximal standard uptake values.The characteristic of lymphoma spreading from primary lesions was also summarized.Serum albumin,LDH,β2-MG,SUVmax,B symptoms were compared in patients with different lymphoma involvement sites.Result：^18F-FDG PET/CT detected lymphoma lesions in at least one site in all of the 22 patients.The more common sites of primary lesions were nasal cavity（81.9%）,nasopharynx（9.1%）,oropharynx（9.1%）.The more frequent sites of the lymphoma lesion were nasal cavity（95.5%）,nasopharynx（54.4%）,lymphoid nodes in right neck（40.9%）,lymphoid nodes in left neck（40.9%）,oropharynx（36.4%）.The primary lymphoma lesion in nasal cavity and pharynx can spread to near sites and tissues.They can not only spread to near lymph nodes but also skip to distant organs.In patients with more lymphoma lesion,the SUVmax of primary lesion and the level of serum β2-MG increased significantly.Conclusion：^18F-FDG PET/CT can accurately detect all lymphoma lesions in patients with extranodal NK/T-cell lymphoma,nasal type.The SUVmax and serumβ2-MG level can reflect the lymphoma load in whole body.
出处
《临床血液学杂志》
CAS
2011年第5期538-540,共3页
Journal of Clinical Hematology
关键词
鼻型结外NK/T细胞淋巴瘤
PET/CT
Β2-微球蛋白
extranodal NK/T-cell lymphoma
nasal type
positron emission tomography/computed tomography
Beta-2-microglobulin
