摘要
目的通过观察无创正压通气(NIPPV)在治疗肺心病伴Ⅱ型呼吸衰竭过程中对脑钠肽前体(NT-proBNP)的影响,了解NT-proBNP与肺心病之间的关系。方法共57例患者,所有患者均于入院时及治疗24h及48h测定BNP及血气分析,均给予一般治疗,其中30例进行NIPPV治疗。治疗前后各指标进行对比,并进行两组间对比。结果所以患者的BNP水平均高于正常。经治疗后两组患者NT-proBNP均较治疗前有显著下降,且两组在治疗后血气各种指标均有明显改善(P<0.05),两组比较,NT-proBNP的改善情况未获得统计学差异。结论肺心病患者血清NT-proBNP均较正常值增高。经治疗后NT-proBNP可显著降低。NT-proBNP可以反映右心室的负荷,对于存在右心室受损时可以作为预测指标。
Objective To study the effects on the change of plasma brain natriuretic peptide（BNP） levels in the patients with chronic pulmonary heart disease received mechanical ventilation.Methods Plasma BNP levels were measured from 57 patients with chronic pulmonary heart disease before and after 24 hours and 48 hours,all pations were given ordinary treatment but 30 of them were geiven mechanical ventilation.analyzing their relationship.Results Plasma BNP levels in patients were higher than those in healthy people;BNP levels after treatment were lower significantly than before.（P0.05）,and both showed perfaction with PH,PaO2 and PaCO2.But has not showed significantly difference in statistics between the two groups.Conclusion Plasma BNP levels can indicate the severity of chronic cor pulmonale in elder people and be improved by treatment for short period.
出处
《中国实用医药》
2011年第28期20-22,共3页
China Practical Medicine
