摘要
目的比较1型、2型糖尿病大鼠牙槽骨骨密度的变化。方法腹腔注射链脲佐菌素制备1型、2型糖尿病大鼠模型,应用定量放免法、酶联免疫吸附法检测其血糖、血脂、胰岛素和骨代谢血清标记指标,采用双能X线照射法测量右侧下颌牙槽骨的骨密度。结果 1型、2型糖尿病组正常对照大鼠的下颌牙槽骨骨密度无统计学差异(P>0.05),2型糖尿病大鼠下颌牙槽骨发生了骨质疏松(P<0.05),1型糖尿病治疗组大鼠下颌牙槽骨未发生骨质疏松(P>0.05),1型糖尿病未治疗组大鼠发生了骨质疏松(P<0.05)。2型糖尿病大鼠下颌牙槽骨骨密度高于1型糖尿病未治疗组(P<0.05),与1型糖尿病治疗组大鼠下颌牙槽骨骨密度接近(P>0.05)。结论 2型糖尿病大鼠下颌牙槽骨骨密度高于1型糖尿病大鼠下颌牙槽骨,控制好血糖浓度可以预防骨质疏松。
Objective To compare the changes of the mineral density of the alveolar bone in Type 1 and Type 2 diabetic rats.Methods Models of diabetic rats were established by peritoneal injection of STZ.Blood glucose,lipid,and serum insulin,indicators of bone metabolism were determined by quantitative radioimmunoassay,enzyme-linked immunosorbent assay,while the bone mineral density of the right alveolar bone was measured by the dual energy X-ray irradiation method.Results The changes of the mineral density alveolar bone of the mandible in normal control rats was similar（P0.05）.Osteoporosis did not happen to treated Type 1 diabetic rats（P0.05）,but it happened to untreated Type 2 diabetic and Type 1 diabetic rats（P0.05）.The changes of the mineral density of the alveolar bone of mandible in treated Type 2 diabetic and Type 1 diabetic rats were similar（P0.05）.Conclusion The mineral density of the alveolar bone of mandible in untreated Type 2 diabetic rats was higher than that in Type 1 diabetic rats.Good control of blood glucose levels can prevent osteoporosis.
出处
《山东大学学报（医学版）》
CAS
北大核心
2011年第9期53-55,62,共4页
Journal of Shandong University:Health Sciences
关键词
1型糖尿病
2型糖尿病
下颌牙槽骨
骨密度
Type 1 diabetes mellitus
Type 2 diabetes mellitus
Alveolar bone of mandible
Bone mineral density
