摘要
目的观察左乙拉西坦(LEV)单药或添加治疗不同类型小儿癫的临床疗效和安全性。方法选取100例于山西省儿童医院小儿神经内科专科门诊2008年8月-2010年10月收治的应用LEV单药或添加治疗的癫患儿为研究对象,采用开放性自身对照随访研究方法。LEV给药起始剂量为10 mg.kg-1.d-1,分2次口服,每周增加上述剂量1次,3～4周增加至目标剂量20～40 mg.kg-1.d-1,随访6～24个月,以发作频率减少的百分率作为疗效判定标准,观察治疗前后发作频率变化、脑电图改变,并记录治疗过程中不良反应的发生情况,以评价其安全性。结果入选癫患儿100例,失访4例。发作完全控制49例(占51.0%);有效27例(占28.1%);无效17例(占17.8%);加重3例(占3.1%)。总有效率为79.1%。脑电图明显改善者8例。14例(14.6%)患儿出现包括情绪异常,7例(7.3%)出现乏力,6例(6.3%)出现嗜睡,1例(1.0%)出现皮疹等不良反应。未发现严重过敏及血液系统抑制、肝肾功能异常等不良反应。2例因不良反应停药。结论 LEV治疗小儿各种类型癫具有良好的疗效和安全性,是一个值得推广的广谱抗癫药物。
Objective To observe the efficacy and safety of levetiracetam （LEV） therapy on different types of epilepsies in children. Methods One hundred cases of children with epilepsy receiving LEV therapy from Shanxi Children＇s Hospital between Aug. 2008 and Oct. 2010 were investigated in the subject. The method of self - controlled and open - label research was performed. The LEV treatment initiated at the dose of 10 mg·kg^-1· d^-1, which was divided into twice daily, the same amounts were added continuously once a week, until the objective dose of 20 - 40 mg · kg^ -1·d ^-1 within 3 - 4 weeks. Observation lasted for 6 - 24 months. Following the judgment standard of the efficacy ： Per- centage reduction of seizure frequency,the efficacy and electroencephalogram （EEG） changes were assessed ,safety was evaluated by recor- ding adverse events. Results Among 100 children ,96 patients were followed up,49 cases （51.0%） achieved seizure -free, 27 children （28.1% ） had at least 50% reduction in seizures but not 100% , 17 cases（ 17.8% ） had inefficacy and 3 cases（3.1% ） had aggravation. The total effective rate was 79.1%. EEG improvemented in 8 cases. The adverse events happened in few cases, including mood and behavioral changes （14 cases, 14.6% ）, asthenia （7 cases ,7.3 % ）, somnolence （6 cases, 6.3 % ）, and skin rashes （1 case, 1.0% ）. Two cases withdrew the treatment for side effects. Conclusion Levetiracetam is of well efficacy and safety for children with various types of epilepsy, should be wildly applied to epileptic children.
出处
《实用儿科临床杂志》
CAS
CSCD
北大核心
2011年第21期1661-1663,共3页
Journal of Applied Clinical Pediatrics
